NATURAL CHOLINESTERASE INHIBITORS HAVE BEEN FOUND IN MANY BIOLOGICAL SOURCES. NINE COMPOUNDS WITH AGAROFURAN (EPOXYEUDESMANE) SKELETONS WERE ISOLATED FROM SEEDS AND AERIAL PARTS OF MAYTENUS DISTICHA AND EUONYMUS JAPONICUS. THE IDENTIFICATION AND STRUCTURAL ELUCIDATION OF COMPOUNDS WERE BASED ON SPECTROSCOPIC DATA ANALYSES. ALL COMPOUNDS HAD INHIBITORY ACETYLCHOLINESTERASE (ACHE) ACTIVITY. THESE NATURAL COMPOUNDS, WHICH POSSESSED MIXED OR UNCOMPETITIVE MECHANISMS OF INHIBITORY ACTIVITY AGAINST ACHE, MAY BE CONSIDERED AS MODELS FOR THE DESIGN AND DEVELOPMENT OF NEW NATURALLY OCCURRING DRUGS FOR MANAGEMENT STRATEGIES FOR NEURODEGENERATIVE DISEASES. THIS IS THE FIRST REPORT OF THESE CHEMICAL STRUCTURES FOR SEEDS OF M. DISTICHA.