Publicación:
TYROSINASE INHIBITORS FROM CALCEOLARIA INTEGRIFOLIA S.L.: CALCEOLARIA TALCANA AERIAL PARTS

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dc.creatorEVELYN DEL PILAR MUÑOZ NÚÑEZ
dc.creatorENRIQUE ADALBERTO WERNER NAVARRETE
dc.creatorCARLOS LEONARDO ARMANDO CÉSPEDES ACUÑA
dc.creatorJULIO ENRIQUE ILDEFONSO ALARCÓN ENOS
dc.date2013
dc.date.accessioned2025-01-10T14:52:59Z
dc.date.available2025-01-10T14:52:59Z
dc.date.issued2013
dc.description.abstractAS A DEFENSE MECHANISM OF THE AERIAL PARTS OF CALCEOLARIA TALCANA (CALCEOLARIACEAE; FORMERLY SCROPHULARIACEAE) AGAINST HERBIVORE OFFENSES AND INSECT PEST ATTACK, DITERPENOIDS, TRITERPENOIDS, PHENYLETHANOIDS, FLAVONOIDS, AND IRIDOIDS ARE RAPIDLY ACCUMULATED ALONG THE AERIAL PARTS, RESULTING IN A UNIQUE NATURAL BIOPESTICIDE COMPLEX FROM THIS PLANT. IN ADDITION TO VERBASCOSIDE A SERIES OF KNOWN COMPOUNDS WERE SCREENED FOR THEIR INHIBITORY ACTIVITY AGAINST MUSHROOM TYROSINASE AND PROTEASE ENZYMES. ETHYL ACETATE AND N-HEXANE EXTRACTS, TOGETHER WITH CYCLOPROPYL-7,15-ENT-PIMARADIENE (1), ABIETATRIENE (2), URSOLIC ACID (3), ?-LUPEOL (4), ?-SITOSTEROL (5), 2-HYDROXY-3-(1,1-DIMETHYLALLYL)-1,4-NAPHTHOQUINONE (6), ?-DUNNIONE (7), VERBASCOSIDE (8), MARTYNOSIDE (9), AND SOME KNOWN MODEL COMPOUNDS PROVED TO BE INHIBITORS OF OXIDATION OF L-3,4-DIHYDROXYPHENYLALANINE (L-DOPA) CATALYZED BY TYROSINASE (EC 1.14.18.1) WITH AN IC50 BETWEEN 10.0 AND 200 PPM OR ?M, RESPECTIVELY, SUGGESTING THAT PHENOLIC MOIETIES IN THE MOLECULES ASSAYED ARE IMPORTANT FOR THE ACTIVITY.
dc.formatapplication/pdf
dc.identifier.doi10.1021/jf400531h
dc.identifier.issn1520-5118
dc.identifier.issn0021-8561
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/9386
dc.languagespa
dc.publisherJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
dc.relation.uri10.1021/jf400531h
dc.rightsPUBLICADA
dc.subjectVERBASCOSIDE
dc.subjectTYROSINASE INHIBITORY ACTIVITY
dc.subjectTRITERPENES
dc.subjectPROTEASE INHIBITION
dc.subjectPLANT?INSECT INTERACTION
dc.subjectPHENYLETHANOIDS
dc.subjectNAPHTHOQUINONES
dc.subjectIRIDOID MONOTERPENES
dc.subjectINSECT GROWTH INHIBITORY ACTIVITY
dc.subjectDITERPENES
dc.subjectDEFENSE MECHANISM
dc.subjectCALCEOLARIA TALCANA
dc.titleTYROSINASE INHIBITORS FROM CALCEOLARIA INTEGRIFOLIA S.L.: CALCEOLARIA TALCANA AERIAL PARTS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE INVESTIGACION
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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