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ADENOSINE KINASE AND CARDIOVASCULAR FETAL PROGRAMMING IN GESTATIONAL DIABETES MELLITUS

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dc.creatorJOSÉ FERNANDO TOLEDO MONTIEL
dc.date2020
dc.date.accessioned2025-01-10T15:13:48Z
dc.date.available2025-01-10T15:13:48Z
dc.date.issued2020
dc.description.abstractGESTATIONAL DIABETES MELLITUS (GDM) IS A DETRIMENTAL CONDITION FOR HUMAN PREGNANCY ASSOCIATED WITH ENDOTHELIAL DYSFUNCTION AND ENDOTHELIAL INFLAMMATION IN THE FETOPLACENTAL VASCULATURE AND LEADS TO INCREASED CARDIO-METABOLIC RISK IN THE OFFSPRING. IN THE FETOPLACENTAL VASCULATURE, GDM IS ASSOCIATED WITH ALTERED ADENOSINE METABOLISM. ADENOSINE IS AN IMPORTANT VASOACTIVE MOLECULE AND IS AN INTERMEDIARY AND FINAL PRODUCT OF TRANSMETHYLATION REACTIONS IN THE CELL. ADENOSINE KINASE IS THE MAJOR REGULATOR OF ADENOSINE LEVELS. DISRUPTION OF THIS ENZYME IS ASSOCIATED WITH ALTERATIONS IN METHYLATION-DEPENDENT GENE EXPRESSION REGULATION MECHANISMS, WHICH ARE ASSOCIATED WITH THE FETAL PROGRAMMING PHENOMENON. HERE WE PROPOSE THAT CELLULAR AND MOLECULAR ALTERATIONS ASSOCIATED WITH GDM CAN DYSREGULATE ADENOSINE KINASE LEADING TO FETAL PROGRAMMING IN THE FETOPLACENTAL VASCULATURE. THIS CAN CONTRIBUTE TO THE CARDIO-METABOLIC LONG-TERM CONSEQUENCES OBSERVED IN OFFSPRING AFTER EXPOSURE TO GDM.
dc.formatapplication/pdf
dc.identifier.doi10.1016/j.bbadis.2019.01.023
dc.identifier.issn0006-3002
dc.identifier.issn0925-4439
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/11029
dc.languagespa
dc.publisherBIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
dc.relation.uri10.1016/j.bbadis.2019.01.023
dc.rightsPUBLICADA
dc.titleADENOSINE KINASE AND CARDIOVASCULAR FETAL PROGRAMMING IN GESTATIONAL DIABETES MELLITUS
dc.title.alternativeADENOSINA QUINASA Y PROGRAMACIÓN FETAL CARDIOVASCULAR EN LA DIABETES MELLITUS GESTACIONAL
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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