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EVIDENCES OF POLYMORPHISM ASSOCIATED WITH CIRCADIAN SYSTEM AND RISK OF PATHOLOGIES: A REVIEW OF THE LITERATURE

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dc.creatorJEANNETTE MARISOL VERA ARAYA
dc.creatorFRANCISCO JAVIER VALENZUELA MELGAREJO
dc.date2016
dc.date.accessioned2025-01-10T14:39:20Z
dc.date.available2025-01-10T14:39:20Z
dc.date.issued2016
dc.description.abstractTHE CIRCADIAN SYSTEM IS A SUPRAPHYSIOLOGICAL SYSTEM THAT MODULATES DIFFERENT BIOLOGICAL FUNCTIONS SUCH AS METABOLISM, SLEEP-WAKE, CELLULAR PROLIFERATION, AND BODY TEMPERATURE. DIFFERENT CHRONODISRUPTORS HAVE BEEN IDENTIFIED, SUCH AS SHIFT WORK, FEEDING TIME, LONG DAYS, AND STRESS. THE ENVIRONMENTAL CHANGES AND OUR MODERN LIFESTYLE CAN ALTER THE CIRCADIAN SYSTEM AND INCREASE THE RISK OF DEVELOPING PATHOLOGIES SUCH AS CANCER, PREECLAMPSIA, DIABETES, AND MOOD DISORDER. THIS SYSTEM IS ORGANIZED BY TRANSCRIPTIONAL/TRANDUCTIONAL FEEDBACK LOOPS OF CLOCK GENES CLOCK, BMAL1, PER1?3, AND CRY1-2. HOW MOLECULAR COMPONENTS OF THE CLOCK ARE ABLE TO INFLUENCE THE DEVELOPMENT OF DISEASES AND THEIR RISK RELATION WITH GENETIC COMPONENTS OF POLYMORPHISM OF CLOCK GENES IS UNKNOWN. THIS RESEARCH DESCRIBES DIFFERENT GENETIC VARIATIONS IN THE POPULATION AND HOW THESE ARE ASSOCIATED WITH RISK OF CANCER, METABOLIC DISEASES SUCH AS DIABETES, OBESITY, AND DYSLIPIDEMIAS, AND ALSO MOOD DISORDERS SUCH AS DEPRESSION, BIPOLAR DISEASE, EXCESSIVE ALCOHOL INTAKE, AND INFERTILITY. FINALLY, THESE FINDINGS WILL NEED TO BE IMPLEMENTED AND EVALUATED AT THE LEVEL OF GENETIC INTERACTION AND HOW THE ENVIRONMENT FACTORS TRIGGER THE EXPRESSION OF THESE PATHOLOGIES WILL BE EXAMINED.
dc.formatapplication/pdf
dc.identifier.doi10.1155/2016/2746909
dc.identifier.issn1687-8345
dc.identifier.issn1687-8337
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/8381
dc.languagespa
dc.publisherInternational Journal of Endocrinology
dc.relation.uri10.1155/2016/2746909
dc.rightsPUBLICADA
dc.titleEVIDENCES OF POLYMORPHISM ASSOCIATED WITH CIRCADIAN SYSTEM AND RISK OF PATHOLOGIES: A REVIEW OF THE LITERATURE
dc.title.alternativeEVIDENCIAS DE POLIMORFISMO ASOCIADO AL SISTEMA CIRCADIANO Y RIESGO DE PATOLOGÍAS: UNA REVISIÓN DE LA LITERATURA
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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