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ASPERGILLUS NIGER CATALYZES THE SYNTHESIS OF FLAVONOIDS FROM CHALCONES

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dc.creatorCARLOS LEONARDO ARMANDO CÉSPEDES ACUÑA
dc.creatorJULIO ENRIQUE ILDEFONSO ALARCÓN ENOS
dc.date2013
dc.date.accessioned2025-01-10T14:32:23Z
dc.date.available2025-01-10T14:32:23Z
dc.date.issued2013
dc.description.abstractFLAVONOIDS, WHICH HAVE MANY BIOLOGICAL ACTIVITIES AND HAVE BEEN WIDELY USED IN NATURE, CAN BE ARTIFICIALLY SYNTHESIZED. HOWEVER, REGIOSELECTIVE CYCLIZATION OF CHALCONES IS DIFFICULT BY CHEMICAL METHODS. IN THIS STUDY, WE DEMONSTRATED THAT ASPERGILLUS NIGER IS CAPABLE OF CYCLIZING CHALCONES TO FLAVANONES, AFFORDING A MIMIC OF PLANT BIOSYNTHETIC PROCESSES. CHALCONES 1?6 WERE BIOTRANSFORMATED TO THE MODIFIED CHALCONES 8?14 AND TO THE FLAVANONES 15?27. THE BIOTRANSFORMATION SHOWED THAT ENZYMATIC CYCLIZATION AND DEMETHYLATION OCCURRED DURING THE FIRST DAYS OF BIOTRANSFORMATION; IN CONTRAST, HYDROXYLATION IS A LATER PROCESS. WITH A LONGER CULTURING TIME, IT IS POSSIBLE TO OBTAIN MORE HYDROXYLATED FLAVANONES WITH EXCELLENT YIELDS
dc.formatapplication/pdf
dc.identifier.doi10.3109/10242422.2013.813489
dc.identifier.issn1029-2446
dc.identifier.issn1024-2422
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/7871
dc.languagespa
dc.publisherBIOCATALYSIS AND BIOTRANSFORMATION
dc.relation.uri10.3109/10242422.2013.813489
dc.rightsPUBLICADA
dc.subjectFLAVONOIDS
dc.subjectCHALCONES BIOTRANSFORMATIÓN
dc.subjectA. NIGER
dc.titleASPERGILLUS NIGER CATALYZES THE SYNTHESIS OF FLAVONOIDS FROM CHALCONES
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE INVESTIGACION
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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