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ANTIOXIDANT AND ANTI-PROLIFERATIVE ACTIVITY OF ESSENTIAL OIL AND MAIN COMPONENTS FROM LEAVES OF ALOYSIA POLYSTACHYA HARVESTED IN CENTRAL CHILE

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dc.creatorENRIQUE ADALBERTO WERNER NAVARRETE
dc.date2021
dc.date.accessioned2025-01-10T15:26:15Z
dc.date.available2025-01-10T15:26:15Z
dc.date.issued2021
dc.description.abstractTHE AIM OF THIS STUDY WAS TO DETERMINE, FIRST, THE CHEMICAL COMPOSITION OF ALOYSIA POLYSTACHYA (GRISEB) MOLDENKE ESSENTIAL OIL, FROM LEAVES HARVESTED IN CENTRAL CHILE; AND SECOND, ITS ANTIOXIDANT AND CYTOTOXIC ACTIVITY. EIGHT COMPOUNDS WERE IDENTIFIED VIA GAS CHROMATOGRAPHY?MASS SPECTROMETRY (GC?MS) ANALYSES, WITH THE MOST REPRESENTATIVE BEING R-CARVONE (91.03%), R-LIMONENE (4.10%), AND DIHYDROCARVONE (1.07%). FOR ALOYSIA POLYSTACHYA ESSENTIAL OIL, ANTIOXIDANT ASSAYS (2,2-DIPHENYL-1-PICRYLHYDRAZYL (DPPH), H2O2, FERRIC REDUCING ANTIOXIDANT POWER (FRAP), AND TOTAL REACTIVE ANTIOXIDANT POTENTIAL (TRAP)) SHOWED GOOD ANTIOXIDANT ACTIVITY COMPARED TO COMMERCIAL ANTIOXIDANT CONTROLS; AND ANTI-PROLIFERATIVE ASSAYS AGAINST THREE HUMAN CANCER CELL LINES (COLON, HT-29; PROSTATE, PC-3; AND BREAST, MCF-7) DETERMINED AN IC50 OF 5.85, 6.74, AND 9.53 ?G/ML, AND SELECTIVITY INDICES OF 4.75, 4.12, AND 2.92 FOR HT-29, PC-3, AND MCF-7, RESPECTIVELY. WE ALSO REPORT ON ASSAYS WITH CCD 841 CON (COLON EPITHELIAL). OVERALL, RESULTS FROM THIS STUDY MAY REPRESENT, IN THE NEAR FUTURE, DEVELOPMENTS FOR NATURAL-BASED CANCER TREATMENTS.
dc.formatapplication/pdf
dc.identifier.doi10.3390/molecules26010131
dc.identifier.issn1420-3049
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/12011
dc.languagespa
dc.publisherMOLECULES
dc.relation.uri10.3390/molecules26010131
dc.rightsPUBLICADA
dc.titleANTIOXIDANT AND ANTI-PROLIFERATIVE ACTIVITY OF ESSENTIAL OIL AND MAIN COMPONENTS FROM LEAVES OF ALOYSIA POLYSTACHYA HARVESTED IN CENTRAL CHILE
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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