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FIRST TRIMESTER MATERNAL VARIABLES AS POTENTIAL PREDICTORS FOR GESTATIONAL DIABETES MELLITUS

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dc.creatorANDRÉS IGNACIO RODRÍGUEZ MORALES
dc.date2021
dc.date.accessioned2025-01-10T15:25:13Z
dc.date.available2025-01-10T15:25:13Z
dc.date.issued2021
dc.description.abstractOBJECTIVES: TO IDENTIFY FIRST TRIMESTER MATERNAL GYNECO-OBSTETRIC VARIABLES THAT MAY BE USEFUL FOR GESTATIONAL DIABETES MELLITUS (GDM) PREDICTION IN CHILEAN PREGNANT WOMEN. METHODS: PREGNANT WOMEN WITH ? 12 GESTATIONAL WEEKS AND WITHOUT PREGESTATIONAL DIABETES WERE RECRUITED IN CONCEPCION, CHILE. DURING THE FIRST TRIMESTER OF PREGNANCY, 19 GYNECO-OBSTETRIC VARIABLES WERE REGISTERED: MATERNAL AGE, HEIGHT, WEIGHT, BODY MASS INDEX, SYSTOLIC PRESSURE, DIASTOLIC PRESSURE, PRIOR GDM, POLYCYSTIC OVARIAN SYNDROME, DIO2 GENOTYPE, FTO GENOTYPE, GLYCEMIA, TSH, TOTAL T3, TOTAL T4, FREE T4, THYROGLOBULIN, THYROGLOBULIN ANTIBODY (TGAB), THYROID PEROXIDASE ANTIBODY (ANTI-TPO) AND TSH RECEPTOR ANTIBODY (TRAB). GDM DIAGNOSIS WAS PERFORMED AT 24-28 GESTATIONAL WEEKS, WITH POSTLOAD GLYCEMIA (75G, 2H) ? 140 MG/DL. OUT OF 39 PREGNANT WOMEN, 6 WERE DIAGNOSED WITH GDM. DATA WERE ANALYZED BY UNIVARIATE AND MULTIVARIATE APPROACHES. FOR UNIVARIATE ANALYSIS, FISHERS EXACT, STUDENTS T AND MANN-WHITNEY TESTS WERE EMPLOYED; WHILE FOR MULTIVARIATE ANALYSIS, THE MACHINE LEARNING TECHNIQUE PRINCIPAL COMPONENT ANALYSIS (PCA) WAS APPLIED. RESULTS: ACCORDING TO THE UNIVARIATE ANALYSIS, THE ONLY FIRST TRIMESTER VARIABLES THAT ENABLE TO DIFFERENTIATE THE GDM GROUP FROM THE NON-GDM ONE ARE SYSTOLIC PRESSURE (P=0.0454) AND PRIOR GDM (P=0.0002). IN CONTRAST, THE MULTIVARIATE ANALYSIS SHOWS THAT GDM PREGNANT WOMEN CAN BE DISTINGUISHED FROM THE NON-GDM ONES BY THE SIXTH PRINCIPAL COMPONENT (PC6, 7% VARIANCE), WHICH IS A LINEAL COMBINATION OF VARIABLES WHERE THE MAIN CONTRIBUTORS ARE: FTO GENOTYPE, PRIOR GDM, TOTAL T3, DIASTOLIC PRESSURE, ANTI-TPO AND TRAB. CONCLUSION: THE FIRST TRIMESTER MATERNAL VARIABLES SYSTOLIC PRESSURE, PRIOR GDM, FTO GENOTYPE, TOTAL T3, DIASTOLIC PRESSURE, ANTI-TPO AND TRAB, ARE RELEVANT TO DISCRIMINATE BETWEEN GDM AND NON-GDM PREGNANT WOMEN. THEREFORE, THEY MAY BE HELPFUL FOR GDM PREDICTION.
dc.formatapplication/pdf
dc.identifier.doi10.1016/j.placenta.2021.07.106
dc.identifier.issn1532-3102
dc.identifier.issn0143-4004
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/11929
dc.languagespa
dc.publisherPLACENTA
dc.relation.uri10.1016/j.placenta.2021.07.106
dc.rightsPUBLICADA
dc.titleFIRST TRIMESTER MATERNAL VARIABLES AS POTENTIAL PREDICTORS FOR GESTATIONAL DIABETES MELLITUS
dc.title.alternativeVARIABLES MATERNAS DEL PRIMER TRIMESTRE COMO POSIBLES PREDICTORES DE DIABETES MELLITUS GESTACIONAL
dc.typeMEETING ABSTRACT
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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