Publicación:
IN VITRO ANTI-TUMORAL AND IMMUNOMODULATORY EFFECTS OF ACIDIC POLYSACCHARIDES ISOLATED FROM THE FUNGUS GLOEOSOMA MIRABILE

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dc.creatorJAIME ROBERTO CABRERA PARDO
dc.date2024
dc.date.accessioned2025-01-10T15:49:30Z
dc.date.available2025-01-10T15:49:30Z
dc.date.issued2024
dc.description.abstractPOLYSACCHARIDES FROM WOOD-ROOTING FUNGI HAVE ATTRACTED ATTENTION DUE TO THEIR BROAD PHARMACOLOGICAL PROPERTIES. HEREIN, WE REPORT THE ANTITUMOR AND IMMUNOMODULATORY ACTIVITIES OF ACID POLYSACCHARIDES ISOLATED FROM FUNGI GLOEOSOMA MIRABILE. THE POLYSACCHARIDE EXTRACTS DISPLAYED SIGNIFICANT ANTIPROLIFERATIVE ACTIVITY AGAINST CANCER CELL LINES (MCF-7, HCT-116, U-937) IN A DOSE-DEPENDENT MANNER AND INDUCTION OF IL-6 IN MACROPHAGE RAW 264.7. FURTHERMORE, FLOW CYTOMETRY ANALYSIS SHOWED THAT HIGH POLYSACCHARIDE CONCENTRATIONS INDUCED APOPTOSIS BY 83% IN HL-60 CELLS. BASED ON GAS CHROMATOGRAPHY?MASS SPECTROMETRY (GC-MS) AND FOURIER TRANSFORM INFRA-RED (FT-IR) SPECTROSCOPY STUDIES, ACIDIC POLYSACCHARIDES FROM G. MIRABILE WERE MAINLY COMPOSED OF ARABINOSE, ?-D-GALACTOPYRANOSE AND METHYL ?-D-GALACTOPYRANOSIDE.
dc.formatapplication/pdf
dc.identifier.doi10.1080/14786419.2024.2335351
dc.identifier.issn1478-6427
dc.identifier.issn1478-6419
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/13824
dc.languagespa
dc.publisherNATURAL PRODUCT RESEARCH
dc.relation.uri10.1080/14786419.2024.2335351
dc.rightsPUBLICADA
dc.subjectIMMUNOMODULATORY EFFECTS OF ACIDIC POLYSACCHARIDES ISOLATED
dc.titleIN VITRO ANTI-TUMORAL AND IMMUNOMODULATORY EFFECTS OF ACIDIC POLYSACCHARIDES ISOLATED FROM THE FUNGUS GLOEOSOMA MIRABILE
dc.typeARTÍCULO
dspace.entity.typePublication
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE QUIMICA
ubb.SedeCONCEPCIÓN
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