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CHEMICAL COMPOSITION, ANTIOXIDANT AND ANTICANCER ACTIVITIES OF LEPTOCARPHA RIVULARIS DC FLOWER EXTRACTS

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dc.creatorENRIQUE ADALBERTO WERNER NAVARRETE
dc.date2021
dc.date.accessioned2025-01-10T15:26:18Z
dc.date.available2025-01-10T15:26:18Z
dc.date.issued2021
dc.description.abstractAN EVALUATION OF ANTIOXIDANT AND ANTICANCER ACTIVITY WAS SCREENED IN LEPTOCARPHA RIVULARIS DC FLOWER EXTRACTS USING FOUR SOLVENTS (N-HEXANE (HEX), DICHLOROMETHANE (DCM), ETHYL ACETATE (ACOET), AND ETHANOL (ETOH)). EXTRACTS WERE COMPARED FOR TOTAL EXTRACT FLAVONOIDS AND PHENOL CONTENTS, ANTIOXIDANT ACTIVITY (2,2-DIPHENYL-1-PICRYL-HYDRAZYL-HYDRATE (DPPH), FERRIC REDUCING ANTIOXIDANT POTENTIAL (FRAP), TOTAL REACTIVE ANTIOXIDANT PROPERTIES (TRAP) AND OXYGEN RADICAL ABSORBANCE CAPACITY (ORAC)) ACROSS A DETERMINED VALUE OF REDUCED/OXIDIZED GLUTATHIONE (GSH/GSSG), AND CELL VIABILITY (THE SULFORHODAMINE B (SRB) ASSAY). THE MOST ACTIVE EXTRACTS WERE ANALYZED BY CHROMATOGRAPHIC ANALYSIS (GC/MS) AND TESTED FOR APOPTOTIC PATHWAYS. EXTRACTS FROM HEX, DCM AND ACOET REDUCED CELL VIABILITY, CAUSED CHANGES IN CELL MORPHOLOGY, AFFECTED MITOCHONDRIAL MEMBRANE PERMEABILITY, AND INDUCED CASPASE ACTIVATION IN TUMOR CELL LINES HT-29, PC-3, AND MCF-7. THESE EFFECTS WERE GENERALLY LESS PRONOUNCED IN THE HEK-293 CELL LINE (NONTUMOR CELLS), INDICATING CLEAR SELECTIVITY TOWARDS TUMOR CELL LINES. WE ATTRIBUTE LIKELY EXTRACT ACTIVITY TO THE PRESENCE OF SESQUITERPENE LACTONES, IN COMBINATION WITH OTHER COMPONENTS LIKE STEROIDS AND FLAVONOIDS.
dc.formatapplication/pdf
dc.identifier.doi10.3390/molecules26010067
dc.identifier.issn1420-3049
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/12015
dc.languagespa
dc.publisherMOLECULES
dc.relation.uri10.3390/molecules26010067
dc.rightsPUBLICADA
dc.titleCHEMICAL COMPOSITION, ANTIOXIDANT AND ANTICANCER ACTIVITIES OF LEPTOCARPHA RIVULARIS DC FLOWER EXTRACTS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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