Publicación:
ENDOPLASMIC RETICULUM STRESS AND DEVELOPMENT OF INSULIN RESISTANCE IN ADIPOSE, SKELETAL, LIVER, AND FOETOPLACENTAL TISSUE IN DIABESITY

Vista sencilla de ítem
dc.creatorJOSÉ FERNANDO TOLEDO MONTIEL
dc.date2019
dc.date.accessioned2025-01-10T15:11:32Z
dc.date.available2025-01-10T15:11:32Z
dc.date.issued2019
dc.description.abstractDIABESITY IS AN ABNORMAL METABOLIC CONDITION SHOWN BY PATIENTS WITH OBESITY THAT DEVELOP TYPE 2 DIABETES MELLITUS. PATIENTS WITH DIABESITY PRESENT WITH INSULIN RESISTANCE, REDUCED VASCULAR RESPONSE TO INSULIN, AND VASCULAR ENDOTHELIAL DYSFUNCTION. ALONG WITH THE SEVERAL WELL-DESCRIBED MECHANISMS OF INSULIN RESISTANCE, A STATE OF ENDOPLASMIC RETICULUM (ER) STRESS, WHERE THE PRIMARY HUMAN TARGETS ARE THE ADIPOSE TISSUE, LIVER, SKELETAL MUSCLE, AND THE FOETOPLACENTAL VASCULATURE, IS APPARENT. ER STRESS CHARACTERISES BY THE ACTIVATION OF THE UNFOLDED PROTEIN RESPONSE VIA THREE CANONICAL ER STRESS SENSORS, I.E., THE PROTEIN KINASE RNA-LIKE ENDOPLASMIC RETICULUM KINASE (PERK), INOSITOL-REQUIRING ENZYME 1? (IRE1?), AND ACTIVATING TRANSCRIPTION FACTOR 6. SLIGHTLY DIFFERENT CELL SIGNALLING MECHANISMS PREFERENTIALLY ENABLE IN DIABESITY IN THE ER STRESS-ASSOCIATED INSULIN RESISTANCE FOR ADIPOSE TISSUE (IRE1?/X-BOX BINDING PROTEIN 1 MRNA SPLICING/C-JUN N-TERMINAL KINASE 1 ACTIVATION), SKELETAL MUSCLE (TRIBBLES-LIKE PROTEIN 3 (TRB3)/PROINFLAMMATORY CYTOKINES ACTIVATION), AND LIVER (PERK/ACTIVATING TRANSCRIPTION FACTOR 4/TRB3 ACTIVATION). THERE IS NO INFORMATION IN HUMAN SUBJECTS WITH DIABESITY IN THE FOETOPLACENTAL VASCULATURE. HOWEVER, THE AVAILABLE LITERATURE SHOWS THAT PREGNANT WOMEN WITH PRE-PREGNANCY OBESITY OR OVERWEIGHT THAT DEVELOP GESTATIONAL DIABETES MELLITUS (GDM) AND THEIR NEWBORN SHOW INSULIN RESISTANCE. ER STRESS IS RECENTLY REPORTED TO BE TRIGGERED IN ENDOTHELIAL CELLS FROM THE HUMAN UMBILICAL VEIN FROM MOTHERS WITH PRE-PREGNANCY OBESITY. HOWEVER, WHETHER A DIFFERENT METABOLIC ALTERATION TO OBESITY IN PREGNANCY OR GDM IS PRESENT IN WOMEN WITH PRE-PREGNANCY OBESITY THAT DEVELOP GDM, IS UNKNOWN. IN THIS REVIEW, WE SUMMARISED THE FINDINGS ON DIABESITY-ASSOCIATED MECHANISMS OF INSULIN RESISTANCE WITH EMPHASIS IN THE PRIMARY TARGETS ADIPOSE, SKELETAL MUSCLE, LIVER, AND FOETOPLACENTAL TISSUES. WE ALSO GIVE EVIDENCE ON THE POSSIBILITY OF A NEW GDM-ASSOCIATED METABOLIC CO
dc.formatapplication/pdf
dc.identifier.doi10.1016/j.mam.2018.11.001
dc.identifier.issn1872-9452
dc.identifier.issn0098-2997
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/10856
dc.languagespa
dc.publisherMOLECULAR ASPECTS OF MEDICINE
dc.relation.uri10.1016/j.mam.2018.11.001
dc.rightsPUBLICADA
dc.titleENDOPLASMIC RETICULUM STRESS AND DEVELOPMENT OF INSULIN RESISTANCE IN ADIPOSE, SKELETAL, LIVER, AND FOETOPLACENTAL TISSUE IN DIABESITY
dc.title.alternativeESTRÉS DEL RETÍCULO ENDOPLÁSMICO Y DESARROLLO DE RESISTENCIA A LA INSULINA EN TEJIDO ADIPOSO, ESQUELÉTICO, HEPÁTICO Y FETOPLACENTARIO EN DIABESIDAD
dc.typeARTÍCULO DE REVISIÓN
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
Archivos
Colecciones
Otros Documentos