Publicación: ANTI-INFLAMMATORY ACTIVITY OF PENSTEMON GENTIANOIDES AND PENSTEMON CAMPANULATUS
Fecha
2011
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PHARMACEUTICAL BIOLOGY
Resumen
CONTEXT: PENSTEMON GENTIANOIDES (KUNTH) POIR. AND PENSTEMON CAMPANULATUS (CAV.) WILLD. (PLANTAGINACEAE) ARE IMPORTANT MEDICINAL PLANTS IN MEXICO USED BY INDIGENOUS PEOPLE FOR THEIR ANTI-INFLAMMATORY EFFECTS AND TO ALSO REDUCE RHEUMATIC PAINS.
OBJECTIVE: IN ADDITION TO RADICAL SCAVENGING ACTIVITY, THE ANTI-INFLAMMATORY ACTIVITY OF THE EXTRACTS, FRACTIONS AND COMPOUNDS OF THESE PLANTS WERE INVESTIGATED AND REPORTED HERE FOR THE FIRST TIME.
MATERIALS AND METHODS: THE ANTI-INFLAMMATORY ACTIVITIES OF MEOH, CH(2)CL(2), AND ETHYL ACETATE EXTRACTS AND IRIDOID, FLAVONOIDS, AND PHENYLPROPANOIDS FROM PENSTEMON GENTIANOIDES AND P. CAMPANULATUS WERE STUDIED IN THE TPA-INDUCED MOUSE EAR EDEMA MODEL. IN ADDITION, ANTIOXIDANT ACTIVITY AGAINST DPPH, CROCIN AND ?-CAROTENE WERE INVESTGATED.
RESULTS: ALL EXTRACTS WERE TESTED AND A SELECTION OF KNOWN COMPOUNDS SIGNIFICANTLY (P
