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PRO-ANGIOGENIC ROLE OF INSULIN: FROM PHYSIOLOGYTO PATHOLOGY

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dc.creatorJESENIA MARIANELA ACURIO JÁCOME
dc.creatorFELIPE ANDRÉS TRONCOSO BASSO
dc.creatorKURT ERWIN HERLITZ FLORES
dc.creatorCARLOS ALONSO ESCUDERO OROZCO
dc.date2017
dc.date.accessioned2025-01-10T14:48:12Z
dc.date.available2025-01-10T14:48:12Z
dc.date.issued2017
dc.description.abstractTHE UNDERLYING MOLECULAR MECHANISMS INVOLVE IN THE REGULATION OF THE ANGIOGENIC PROCESS BY INSULIN ARE NOT WELL UNDERSTOOD. IN THIS REVIEW ARTICLE, WE AIM TO DESCRIBE THE ROLE OF INSULIN AND INSULIN RECEPTOR ACTIVATION ON THE CONTROL OF ANGIOGENESIS AND HOW THESE MECHANISMS CAN BE DEREGULATED IN HUMAN DISEASES. FUNCTIONAL EXPRESSION OF INSULIN RECEPTORS AND THEIR SIGNALING PATHWAYS HAS BEEN DESCRIBED ON ENDOTHELIAL CELLS AND PERICYTES, BOTH OF THE MAIN CELLS INVOLVED IN VESSEL FORMATION AND MATURATION. CONSEQUENTLY, INSULIN HAS BEEN SHOWN TO REGULATE ENDOTHELIAL CELL MIGRATION, PROLIFERATION, AND IN VITRO TUBULAR STRUCTURE FORMATION THROUGH BINDING TO ITS RECEPTORS AND ACTIVATION OF INTRACELLULAR PHOSPHORYLATION CASCADES. FURTHERMORE, INSULIN-MEDIATED PRO-ANGIOGENIC STATE IS POTENTIATED BY GENERATION OF VASCULAR GROWTH FACTORS, SUCH AS THE VASCULAR ENDOTHELIAL GROWTH FACTOR, PRODUCED BY ENDOTHELIAL CELLS. ADDITIONALLY, DISEASES SUCH AS INSULIN RESISTANCE, OBESITY, DIABETES, AND CANCER MAY BE ASSOCIATED WITH THE DEREGULATION OF INSULIN-MEDIATED ANGIOGENESIS. DESPITE THIS KNOWLEDGE, THE UNDERLYING MOLECULAR MECHANISMS NEED TO BE ELUCIDATED IN ORDER TO PROVIDE NEW INSIGHTS INTO THE ROLE OF INSULIN ON ANGIOGENESIS.
dc.formatapplication/pdf
dc.identifier.doi10.3389/fphys.2017.00204
dc.identifier.issn1664-042X
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/9036
dc.languagespa
dc.publisherFrontiers in Physiology
dc.relation.uri10.3389/fphys.2017.00204
dc.rightsPUBLICADA
dc.titlePRO-ANGIOGENIC ROLE OF INSULIN: FROM PHYSIOLOGYTO PATHOLOGY
dc.title.alternativePAPEL PROANGIOGÉNICO DE LA INSULINA: DE LA FISIOLOGÍA A LA PATOLOGÍA
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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