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DISRUPTION OF THE MOUSE BLOOD-BRAIN BARRIER BY SMALL EXTRACELLULAR VESICLES FROM HYPOXIC HUMAN PLACENTAS

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dc.creatorHERMES SEBASTIƁN SANDOVAL RIVAS
dc.creatorCARLOS ALONSO ESCUDERO OROZCO
dc.date2024
dc.date.accessioned2025-01-10T15:47:46Z
dc.date.available2025-01-10T15:47:46Z
dc.date.issued2024
dc.description.abstractCEREBROVASCULAR COMPLICATIONS, INCLUDING CEREBRAL EDEMA AND ISCHEMIC AND HEMORRHAGIC STROKE, CONSTITUTE THE LEADING CAUSE OF MATERNAL MORTALITY ASSOCIATED WITH PREECLAMPSIA. THE UNDERLYING MECHANISMS OF THESE CEREBROVASCULAR COMPLICATIONS REMAIN UNCLEAR. HOWEVER, THEY ARE LINKED TO PLACENTAL DYSFUNCTION AND BLOODBRAIN BARRIER (BBB) DISRUPTION. NEVERTHELESS, THE CONNECTION BETWEEN THESE TWO DISTANT ORGANS IS STILL BEING DETERMINED. INCREASING EVIDENCE SUGGESTS THAT THE PLACENTA RELEASES SIGNALING MOLECULES, INCLUDING EXTRACELLULAR VESICLES, INTO MATERNAL CIRCULATION. EXTRACELLULAR VESICLES ARE CATEGORIZED ACCORDING TO THEIR SIZE, WITH SMALL EXTRACELLULAR VESICLES (SEVS SMALLER THAN 200 NM IN DIAMETER) CONSIDERED CRITICAL SIGNALING PARTICLES IN BOTH PHYSIOLOGICAL AND PATHOLOGICAL CONDITIONS. IN PREECLAMPSIA, THERE IS AN INCREASED NUMBER OF CIRCULATING SEVS IN MATERNAL CIRCULATION, THE SIGNALING FUNCTION OF WHICH IS NOT WELL UNDERSTOOD. PLACENTAL SEVS RELEASED IN PREECLAMPSIA OR FROM NORMAL PREGNANCY PLACENTAS EXPOSED TO HYPOXIA INDUCE BRAIN ENDOTHELIAL DYSFUNCTION AND DISRUPTION OF THE BBB.
dc.formatapplication/pdf
dc.identifier.doi10.3791/65867
dc.identifier.issn1940-087X
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/13689
dc.languagespa
dc.publisherJove-Journal of Visualized Experiments
dc.relation.uri10.3791/65867
dc.rightsPUBLICADA
dc.subjectPREECLAMPTIC WOMEN
dc.subjectPERMEABILITY ROLE
dc.subjectNORMAL-PREGNANCY
dc.subjectINCREASES
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectCELLS
dc.subjectANGIOGENESIS
dc.titleDISRUPTION OF THE MOUSE BLOOD-BRAIN BARRIER BY SMALL EXTRACELLULAR VESICLES FROM HYPOXIC HUMAN PLACENTAS
dc.typeARTƍCULO
dspace.entity.typePublication
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIƓN Y DESARROLLO (EX CONICYT)
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLƁN
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