Publicación:
DUAL-ACTION GEMCITABINE DELIVERY: CHITOSAN-MAGNETITE-ZEOLITE CAPSULES FOR TARGETED CANCER THERAPY AND ANTIBACTERIAL DEFENSE

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dc.creatorYULY ANDREA GUARIN GONZALEZ
dc.creatorGERARDO ANDRÉS CABELLO GUZMÁN
dc.creatorGALO CÁRDENAS TRIVIÑO
dc.date2024
dc.date.accessioned2025-01-10T15:53:40Z
dc.date.available2025-01-10T15:53:40Z
dc.date.issued2024
dc.description.abstractCANCER AND INFECTIOUS DISEASES ARE TWO OF THE WORLD?S MAJOR PUBLIC HEALTH PROBLEMS. GEMCITABINE (GEM) IS AN EFFECTIVE CHEMOTHERAPEUTIC AGENT AGAINST SEVERAL TYPES OF CANCER. IN THIS STUDY, WE DEVELOPED MACROCAPSULES INCORPORATING GEM INTO A CHITOSAN MATRIX BLENDED WITH MAGNETITE AND ZEOLITE BY IONIC GELATION. PHYSICOCHEMICAL CHARACTERIZATION WAS PERFORMED USING HRTEM-ED, XRD, FESEM?EDS, FT-IR, TGA, ENCAPSULATION EFFICIENCY (%E.E.), AND RELEASE PROFILES AT PHS 7.4 AND 5.0. CELL VIABILITY TESTS AGAINST A549 AND H1299 CELL LINES, AND MICROBIOLOGICAL PROPERTIES AGAINST STAPHYLOCOCCAL STRAINS WERE PERFORMED. OUR RESULTS REVEALED THE SUCCESSFUL PRODUCTION OF HEMISPHERICAL CAPSULES WITH AN AVERAGE DIAMETER OF 1.22 MM, A ROUGH SURFACE, AND CHARACTERISTIC FT-IR MATERIAL INTERACTION BADS. THE MACROCAPSULES SHOWED A HIGH GEM ENCAPSULATION EFFICIENCY OF OVER 86% AND CONTROLLED RELEASE OVER 24 H. CELL VIABILITY ASSAYS REVEALED THAT SIMILAR CYTOTOXIC EFFECTS TO FREE GEM WERE ACHIEVED WITH A 45-FOLD LOWER GEM CONCENTRATION, SUGGESTING REDUCED DOSING REQUIREMENTS AND POTENTIALLY FEWER SIDE EFFECTS. ADDITIONALLY, THE MACROCAPSULES DEMONSTRATED POTENT ANTIMICROBIAL ACTIVITY, REDUCING STAPHYLOCOCCUS EPIDERMIDIS GROWTH BY OVER 90%. THESE RESULTS HIGHLIGHT THE MACROCAPSULES DUAL ROLE AS A CHEMOTHERAPEUTIC AND ANTIMICROBIAL AGENT, OFFERING A PROMISING STRATEGY FOR TREATING LUNG CANCER IN PATIENTS AT RISK OF INFECTIOUS DISEASES OR WHO ARE IMMUNOSUPPRESSED.
dc.formatapplication/pdf
dc.identifier.doi10.3390/gels10100672
dc.identifier.issn2310-2861
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/14149
dc.languagespa
dc.publisherGELS
dc.relation.uri10.3390/gels10100672
dc.rightsOPEN ACCESS
dc.subjectZeolite clinoptilolite
dc.subjectMagnetic nanoparticles
dc.subjectIonic gelation
dc.subjectGemcitabine
dc.subjectDrug carriers
dc.subjectChitosan
dc.titleDUAL-ACTION GEMCITABINE DELIVERY: CHITOSAN-MAGNETITE-ZEOLITE CAPSULES FOR TARGETED CANCER THERAPY AND ANTIBACTERIAL DEFENSE
dc.typeARTÍCULO
dspace.entity.typePublication
oaire.licenseConditionCC BY 4.0
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN MADERAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN MADERAS
ubb.SedeCONCEPCIÓN
ubb.SedeCHILLÁN
ubb.SedeCONCEPCIÓN
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