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EXPLORING THE MULTI-TARGET NEUROPROTECTIVE CHEMICAL SPACE OF BENZOFURAN SCAFFOLDS: A NEW STRATEGY IN DRUG DEVELOPMENT FOR ALZHEIMERS DISEASE

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dc.creatorJAIME ROBERTO CABRERA PARDO
dc.date2020
dc.date.accessioned2025-01-10T15:09:43Z
dc.date.available2025-01-10T15:09:43Z
dc.date.issued2020
dc.description.abstractALZHEIMERS DISEASE (AD) IS AN IRREVERSIBLE AND PROGRESSIVE NEURODEGENERATIVE DISORDER THAT SLOWLY DESTROYS MEMORY. THE PRECISE MECHANISM OF AD IS STILL NOT ENTIRELY UNDERSTOOD AND REMAINS UNDER DISCUSSION; IT IS BELIEVED TO BE A MULTIFACTORIAL DISEASE IN WHICH A NUMBER OF MECHANISMS ARE INVOLVED IN ITS PATHOGENESIS. WORLDWIDE, NEAR 37 MILLION PEOPLE SUFFER FROM THE EFFECTS OF AD. AS A CAUSE OF DEATH FOR ELDERLY, IT IS PREDICTED THAT AD WILL RANK THIRD IN THE COMING YEARS, JUST BEHIND CANCER AND HEART DISEASE. UNFORTUNATELY, AD REMAINS AN INCURABLE CONDITION. DESPITE THE DEVASTATING PROBLEMS ASSOCIATED WITH AD, THERE ARE ONLY FOUR FDA APPROVED DRUGS FOR PALLIATIVE TREATMENT OF THIS PATHOLOGY. HENCE, RENEWED SCIENTIFIC EFFORTS ARE REQUIRED NOT ONLY TO UNCOVER MORE INSIGHTS INTO THE AD PROCESS BUT ALSO TO DEVELOP MORE EFFICIENT PHARMACOLOGICAL TOOLS AGAINST THIS DISEASE. DUE TO THE COMPLEXITY AND MULTIPLE MECHANISMS AT PLAY IN THE PROGRESSION OF AD, THE DEVELOPMENT OF DRUGS BY RATIONAL DESIGN IS EXTREMELY DIFFICULT. THE EXISTING DRUGS TO FIGHT AGAINST ALZHEIMERS HAVE HAD LIMITED SUCCESS, MAINLY DUE TO THEIR ABILITY TO MODULATE ONLY ONE OF THE MECHANISMS INVOLVED IN AD. AS OPPOSED TO SINGLE-TARGETED STRATEGIES, THE IDENTIFICATION OF SMALL MOLECULES ABLE TO AFFECT MULTIPLE PATHWAYS INVOLVED IN ALZHEIMERS IS A PROMISING STRATEGY TO DEVELOP MORE EFFICIENT MEDICINES AGAINST THIS DISEASE. CENTRAL TO EXISTING EFFORTS TO DEVELOP PHARMACEUTICALS CONTROLLING AD IS THE DISCOVERY OF NEW CHEMICALS DISPLAYING STRONG NEUROACTIVITY. BENZOFURANS ARE PRIVILEGED OXYGEN CONTAINING HETEROCYCLES THAT HAVE A STRONG NEUROPROTECTIVE BEHAVIOR, INHIBITING SEVERAL OF THE IMPORTANT EVENTS INVOLVED IN THE AD PROCESS. IN THIS REVIEW, AN APPROACH IS PRESENTED THAT RELIES ON EXPANDING THE NEUROPROTECTIVE CHEMICAL SPACE OF BENZOFURAN SCAFFOLDS BY ACCESSING THEM FROM ANDEAN-PATAGONIAN FUNGI AND SYNTHETIC SOURCES (CHEMICAL LIBRARIES).
dc.formatapplication/pdf
dc.identifier.doi10.3389/fphar.2019.01679
dc.identifier.issn1663-9812
dc.identifier.issn1663-9812
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/10713
dc.languagespa
dc.publisherFrontiers in Pharmacology
dc.relation.uri10.3389/fphar.2019.01679
dc.rightsPUBLICADA
dc.titleEXPLORING THE MULTI-TARGET NEUROPROTECTIVE CHEMICAL SPACE OF BENZOFURAN SCAFFOLDS: A NEW STRATEGY IN DRUG DEVELOPMENT FOR ALZHEIMERS DISEASE
dc.title.alternativeEXPLORANDO EL ESPACIO QUÍMICO NEUROPROTECTOR MULTIOBJETIVO DE LOS ANDAMIOS DE BENZOFURANO: UNA NUEVA ESTRATEGIA EN EL DESARROLLO DE FÁRMACOS PARA LA ENFERMEDAD DE ALZHEIMER
dc.typeARTÍCULO DE REVISIÓN
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE QUIMICA
ubb.SedeCONCEPCIÓN
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