Publicación: BIOINFORMATIC DETECTION OF E47, E2F1 AND SREBP1 TRANSCRIPTION FACTORS AS POTENTIAL REGULATORS OF GENES ASSOCIATED TO ACQUISITION OF ENDOMETRIAL RECEPTIVITY
Fecha
2011
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Reproductive Biology and Endocrinology
Resumen
BACKGROUND: THE ENDOMETRIUM IS A DYNAMIC TISSUE WHOSE CHANGES ARE DRIVEN BY THE OVARIAN STEROIDAL HORMONES. ITS MAIN FUNCTION IS TO PROVIDE AN ADEQUATE SUBSTRATE FOR EMBRYO IMPLANTATION. USING MICROARRAY TECHNOLOGY, SEVERAL REPORTS HAVE PROVIDED THE GENE EXPRESSION PATTERNS OF HUMAN ENDOMETRIAL TISSUE DURING THE WINDOW OF IMPLANTATION. HOWEVER IT IS REQUIRED THAT BIOLOGICAL CONNECTIONS BE MADE ACROSS THESE GENOMIC DATASETS TO TAKE FULL ADVANTAGE OF THEM. THE OBJECTIVE OF THIS WORK WAS TO PERFORM A RESEARCH SYNTHESIS OF AVAILABLE GENE EXPRESSION PROFILES RELATED TO ACQUISITION OF ENDOMETRIAL RECEPTIVITY FOR EMBRYO IMPLANTATION, IN ORDER TO GAIN INSIGHTS INTO ITS MOLECULAR BASIS AND REGULATION.
METHODS: GENE EXPRESSION DATASETS WERE INTERSECTED TO DETERMINE A CONSENSUS ENDOMETRIAL RECEPTIVITY TRANSCRIPT LIST (CERTL). FOR THIS CLUSTER OF GENES WE DETERMINED THEIR FUNCTIONAL ANNOTATIONS USING AVAILABLE WEB-BASED DATABASES. IN ADDITION, PROMOTER SEQUENCES WERE ANALYZED TO IDENTIFY PUTATIVE TRANSCRIPTION FACTOR BINDING SITES USING BIOINFORMATICS TOOLS AND DETERMINED OVER-REPRESENTED FEATURES.
