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MICROENCAPSULATION OF ERLOTINIB AND NANOMAGNETITE SUPPORTED IN CHITOSAN AS POTENTIAL ONCOLOGIC CARRIER

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dc.creatorGALO CÁRDENAS TRIVIÑO
dc.date2021
dc.date.accessioned2025-01-10T15:24:55Z
dc.date.available2025-01-10T15:24:55Z
dc.date.issued2021
dc.description.abstractMICROCAPSULES (MC) BASED ON CHITOSAN (CH) AND INCLUDING NANO-MAGNETITE AND ERLOTINIB WERE SYNTHESIZED. THE MICROPARTICLES WERE CHARACTERIZED BY SEM, FT-IR AND TGA. THE PERCENTAGE OF ENCAPSULATION WAS DETERMINED, AS WELL AS ITS MICROBIOLOGICAL ACTIVITY. FINALLY, THE EFFECTIVENESS OF THE FORMULATION WAS EVALUATED IN TERMS OF CELL VIABILITY AND/OR TOXICITY WHEN COMPARED WITH THE REFERENCE DRUG. THE FORMULATION USED TO PREPARE THE MICROCAPSULES SHOWED SOME BACTERIOSTATIC PROPERTIES. THE CHARACTERIZATION OF MICROCAPSULES EXHIBITED AMORPHOUS SPHERICAL SHAPE AND AVERAGE SIZE OF 1.29, 1.58 AND 1.62 MM FOR CHITOSAN, CHITOSAN + NANOMAGNETITE AND CHITOSAN + NANOMAGNETITE + ERLOTINIB, RESPECTIVELY. THE INFRARED SPECTRA SHOWED CHARACTERISTIC BANDS OF THE ERLOTINIB AND MAGNETITE, CONFIRMING ITS INTERNALIZATION. THE THERMOGRAVIMETRIC ANALYZES INDICATED THAT THE MATERIALS DO NOT UNDERGO CHANGES AT OPTIMUM WORKING TEMPERATURES. THE HPLC ANALYSIS SHOWED A 52% OF ENCAPSULATION. FINALLY, THE FORMULATION PROBED HAD LOWER EFFECTIVENESS AND LESS CYTOTOXICITY, THAN THE DRUG WITHOUT ENCAPSULATING """"IN VITRO"""" STUDIES. FOR THAT REASON SEVERAL ASSAYS ARE IN PROGRESS.
dc.formatapplication/pdf
dc.identifier.doi10.3390/polym13081244
dc.identifier.issn2073-4360
dc.identifier.issn2073-4360
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/11906
dc.languagespa
dc.publisherPolymers
dc.relation.uri10.3390/polym13081244
dc.rightsPUBLICADA
dc.titleMICROENCAPSULATION OF ERLOTINIB AND NANOMAGNETITE SUPPORTED IN CHITOSAN AS POTENTIAL ONCOLOGIC CARRIER
dc.title.alternativeMICROENCAPSULACIÓN DE ERLOTINIB Y NANOMAGNETITA APOYADA EN QUITOSANO COMO POTENCIAL PORTADOR ONCOLÓGICO
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN MADERAS
ubb.SedeCONCEPCIÓN
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