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DIHYDROAGAROFURANOID SESQUITERPENES AS ACETYLCHOLINESTERASE INHIBITORS FROM CELASTRACEAE PLANTS: MAYTENUS DISTICHA AND EUONYMUS JAPONICUS

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dc.creatorEVELYN DEL PILAR MUÑOZ NÚÑEZ
dc.creatorCRISTIAN ALEJANDRO BALBONTÍN SEPÚLVEDA
dc.creatorCARLOS LEONARDO ARMANDO CÉSPEDES ACUÑA
dc.creatorJULIO ENRIQUE ILDEFONSO ALARCÓN ENOS
dc.date2015
dc.date.accessioned2025-01-10T14:36:26Z
dc.date.available2025-01-10T14:36:26Z
dc.date.issued2015
dc.description.abstractNATURAL CHOLINESTERASE INHIBITORS HAVE BEEN FOUND IN MANY BIOLOGICAL SOURCES. NINE COMPOUNDS WITH AGAROFURAN (EPOXYEUDESMANE) SKELETONS WERE ISOLATED FROM SEEDS AND AERIAL PARTS OF MAYTENUS DISTICHA AND EUONYMUS JAPONICUS. THE IDENTIFICATION AND STRUCTURAL ELUCIDATION OF COMPOUNDS WERE BASED ON SPECTROSCOPIC DATA ANALYSES. ALL COMPOUNDS HAD INHIBITORY ACETYLCHOLINESTERASE (ACHE) ACTIVITY. THESE NATURAL COMPOUNDS, WHICH POSSESSED MIXED OR UNCOMPETITIVE MECHANISMS OF INHIBITORY ACTIVITY AGAINST ACHE, MAY BE CONSIDERED AS MODELS FOR THE DESIGN AND DEVELOPMENT OF NEW NATURALLY OCCURRING DRUGS FOR MANAGEMENT STRATEGIES FOR NEURODEGENERATIVE DISEASES. THIS IS THE FIRST REPORT OF THESE CHEMICAL STRUCTURES FOR SEEDS OF M. DISTICHA.
dc.formatapplication/pdf
dc.identifier.doi10.1021/acs.jafc.5b04168
dc.identifier.issn1520-5118
dc.identifier.issn0021-8561
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/8166
dc.languagespa
dc.publisherJOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
dc.relation.uri10.1021/acs.jafc.5b04168
dc.rightsPUBLICADA
dc.subjectMAYTENUS DISTICHA
dc.subjectEUONIMUS JAPONICUS
dc.subjectEUDESMANOLIDES
dc.subjectDIHYDROAGAROFURANS
dc.subjectCELASTRACEAE
dc.subjectACETYLCHOLINESTERASE
dc.titleDIHYDROAGAROFURANOID SESQUITERPENES AS ACETYLCHOLINESTERASE INHIBITORS FROM CELASTRACEAE PLANTS: MAYTENUS DISTICHA AND EUONYMUS JAPONICUS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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