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A MULTIDIMENSIONAL STUDY FOR DESIGN FUNCTIONAL FOODS: CHEMICAL PROFILING, ANTIOXIDANT POTENTIAL, ENZYME INHIBITION, AND CYTOTOXIC EFFECTS OF ALKANNA TUBULOSA EXTRACTS

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dc.creatorCARLOS LEONARDO ARMANDO CÉSPEDES ACUÑA
dc.date2024
dc.date.accessioned2025-01-10T15:52:51Z
dc.date.available2025-01-10T15:52:51Z
dc.date.issued2024
dc.description.abstractTHIS STUDY FOCUSES ON THE EXTRACTION OF PLANT SPECIES ALKANNA TUBULOSA GROWING IN TURKEY, USING SOLVENTS OF DIFFERENT POLARITIES (ETHYL ACETATE, ETHANOL, ETHANOL/WATER, AND WATER) AND DETERMINING THEIR CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY. THE EXTRACTS WERE SUBJECTED TO QUALITATIVE LC-MS/MS ANALYSES, WHICH RESULTED IN THE IDENTIFICATION OF EVEN 50 DIFFERENT SECONDARY METABOLITES IN SOME EXTRACTS. THE EXISTENCE OF TOTAL PHENOLS AND FLAVONOIDS WAS DETERMINED. OF TOTAL PHENOLS AND FLAVONOIDS WAS DETERMINED. THE ANTIOXIDANT CAPACITY WAS EVALUATED BY VARIOUS IN VITRO ASSAYS, AS WELL AS THE ENZYME INHIBITORY CAPACITY AGAINST CHOLINESTERASES (ACHE AND BCHE), TYROSINASE, ALPHA-AMYLASE, AND ALPHA-GLUCOSIDASE, AS WELL AS HUMAN ISOFORMS OF CARBONIC ANHYDRASE. IN ADDITION, THE CYTOTOXIC ACTIVITY OF THE EXTRACTS WAS ALSO EXAMINED. THE RESULTS SHOWED THAT THE ETHANOL/WATER EXTRACT SHOWED THE STRONGEST ANTIOXIDANT ACTIVITY (225.55 MG TE/G EXTRACT IN ABTS AND 381.14 MG TE/G EXTRACT IN CUPRAC), PROBABLY DUE TO THE HIGH TOTAL PHENOL (105.17 MG GAE/G EXTRACT) AND FLAVONOIDS (20.12 MG RE/G EXTRACT) CONTENT, WHILE THE ETHANOL EXTRACT SHOWED THE STRONGEST ENZYME INHIBITORY POTENTIAL. THESE CHEMICAL AND BIOLOGICAL FINDINGS PROVIDE VALUABLE INSIGHTS FOR POTENTIAL FUTURE PRODUCTS BASED ON THE A. TUBULOSA EXTRACTS WHICH COULD BE USED IN VARIOUS INDUSTRIES.
dc.formatapplication/pdf
dc.identifier.doi10.1016/j.fbio.2024.104280
dc.identifier.issn2212-4306
dc.identifier.issn2212-4292
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/14086
dc.languagespa
dc.publisherFOOD BIOSCIENCE
dc.relation.uri10.1016/j.fbio.2024.104280
dc.rightsPUBLICADA
dc.subjectCytotoxic
dc.subjectCarbonic anhydrase
dc.subjectBioactive agents
dc.subjectAlkanna tubulosa
dc.subjectAcetylcholinesterase
dc.titleA MULTIDIMENSIONAL STUDY FOR DESIGN FUNCTIONAL FOODS: CHEMICAL PROFILING, ANTIOXIDANT POTENTIAL, ENZYME INHIBITION, AND CYTOTOXIC EFFECTS OF ALKANNA TUBULOSA EXTRACTS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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