Publicación:
AN OUTSIDE-IN SWITCH IN INTEGRIN SIGNALING CAUSED BY CHEMICAL AND MECHANICAL SIGNALS IN REACTIVE ASTROCYTES

dc.creatorANDRÉS IGNACIO RODRÍGUEZ MORALES
dc.date2021
dc.date.accessioned2025-01-10T15:22:58Z
dc.date.available2025-01-10T15:22:58Z
dc.date.issued2021
dc.description.abstractASTROCYTE REACTIVITY IS ASSOCIATED WITH POOR REPAIR CAPACITY AFTER INJURY TO THE BRAIN, WHERE CHEMICAL AND PHYSICAL CHANGES OCCUR IN THE DAMAGED ZONE. ASTROCYTE SURFACE PROTEINS, SUCH AS INTEGRINS, ARE UPREGULATED, AND THE RELEASE OF PRO-INFLAMMATORY MOLECULES AND EXTRACELLULAR MATRIX (ECM) PROTEINS UPON DAMAGE GENERATE A STIFFER MATRIX. INTEGRINS PLAY AN IMPORTANT ROLE IN TRIGGERING A REACTIVE PHENOTYPE IN ASTROCYTES, AND WE HAVE REPORTED THAT ? V ?3 INTEGRIN BINDS TO THE THY-1 (CD90) NEURONAL GLYCOPROTEIN, INCREASING ASTROCYTE CONTRACTILITY AND MOTILITY. ALTERNATIVELY, ? V ?3 INTEGRIN SENSES MECHANICAL FORCES GENERATED BY THE INCREASED ECM STIFFNESS. UNTIL NOW, THE ASSOCIATION BETWEEN THE ? V ?3 INTEGRIN MECHANORECEPTOR RESPONSE IN ASTROCYTES AND CHANGES IN THEIR REACTIVE PHENOTYPE IS UNCLEAR. TO STUDY THE RESPONSE TO COMBINED CHEMICAL AND MECHANICAL STRESS, ASTROCYTES WERE STIMULATED WITH THY-1-PROTEIN A-COATED MAGNETIC BEADS AND EXPOSED TO A MAGNETIC FIELD TO GENERATE MECHANICAL TENSION. WE EVALUATED THE EFFECT OF SUCH STIMULATION ON CELL ADHESION AND CONTRACTION. WE ALSO ASSESSED TRACTION FORCES AND THEIR EFFECT ON CELL MORPHOLOGY, AND INTEGRIN SURFACE EXPRESSION. MECHANICAL STRESS ACCELERATED THE RESPONSE OF ASTROCYTES TO THY-1 ENGAGEMENT OF INTEGRIN RECEPTORS, RESULTING IN CELL ADHESION AND CONTRACTION. ASTROCYTE CONTRACTION THEN EXERTED TRACTION FORCES ONTO THE ECM, INDUCING FASTER CELL CONTRACTILITY AND HIGHER TRACTION FORCES THAN THY-1 ALONE. THEREFORE, CELL-EXTRINSIC CHEMICAL AND MECHANICAL SIGNALS REGULATE IN AN OUTSIDE-IN MANNER, ASTROCYTE REACTIVITY BY INDUCING INTEGRIN UPREGULATION, LIGATION, AND SIGNALING EVENTS THAT PROMOTE CELL CONTRACTION. THESE CHANGES IN TURN GENERATE CELL-INTRINSIC SIGNALS THAT INCREASE TRACTION FORCES EXERTED ONTO THE ECM (INSIDE-OUT). THIS STUDY REVEALS ? V ?3 INTEGRIN MECHANORECEPTOR AS A NOVEL TARGET TO REGULATE THE HARMFUL EFFECTS OF REACTIVE ASTROCYTES IN NEURONAL HEALING.
dc.formatapplication/pdf
dc.identifier.doi10.3389/fcell.2021.712627
dc.identifier.issn2296-634X
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/11750
dc.languagespa
dc.publisherFRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
dc.relation.uri10.3389/fcell.2021.712627
dc.rightsPUBLICADA
dc.titleAN OUTSIDE-IN SWITCH IN INTEGRIN SIGNALING CAUSED BY CHEMICAL AND MECHANICAL SIGNALS IN REACTIVE ASTROCYTES
dc.title.alternativeUN INTERRUPTOR DE AFUERA HACIA ADENTRO EN LA SEÑALIZACIÓN DE INTEGRINA CAUSADA POR SEÑALES QUÍMICAS Y MECÁNICAS EN ASTROCITOS REACTIVOS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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