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BOLDO RESTORES VASCULARIZATION AND REDUCES SKELETAL MUSCLE INFLAMMATION IN SYMPTOMATIC MICE WITH DYSFERLINOPATHY

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dc.creatorCARLOS ALONSO ESCUDERO OROZCO
dc.date2025
dc.date.accessioned2026-11-12T18:50:38Z
dc.date.available2026-11-12T18:50:38Z
dc.date.issued2025
dc.description.abstractDYSFERLINOPATHIES ARE PROGRESSIVE MUSCULAR DYSTROPHIES CAUSED BY DYSF MUTATIONS, LEADING TO IMPAIRED MEMBRANE REPAIR, CHRONIC INFLAMMATION, LIPID ACCUMULATION, AND MUSCLE DEGENERATION. NO APPROVED THERAPIES CURRENTLY HALT THE PROGRESSION OF THIS DISEASE. HERE, WE EVALUATED THE EFFECTS OF DAILY ORAL ADMINISTRATION OF PULVERIZED BOLDO (PEUMUS BOLDUS) LEAVES, COMMONLY USED AS A NUTRACEUTICAL, TO BLAJ MICE, A MODEL OF DYSFERLINOPATHY. SYMPTOMATIC BIAJ MICE WERE TREATED FOR FOUR WEEKS WITH BOLDO AND PRESENTED SIGNIFICANTLY IMPROVED GRIP STRENGTH AND RESTORED ENDOTHELIAL-DEPENDENT VASODILATION. MUSCLE PERFUSION AND CAPILLARY DENSITY IN THE GASTROCNEMIUS WERE BOTH ENHANCED BY TREATMENT. HISTOLOGICAL ANALYSES REVEALED THAT BOLDO PREVENTED MYOFIBER ATROPHY, REDUCED CENTRALLY NUCLEATED FIBERS, AND IMPROVED MUSCLE TISSUE ARCHITECTURE. LIPID ACCUMULATION OBSERVED IN BLAJ MUSCLES WAS ABSENT IN BOLDO-TREATED MICE. AT THE CELLULAR LEVEL, BOLDO NORMALIZED SARCOLEMMA MEMBRANE PERMEABILITY (DYE UPTAKE) AND REDUCED MRNA LEVELS OF INFLAMMASOME COMPONENTS (NLRP3, ASC, AND IL-1?), SUGGESTING ANTI-INFLAMMATORY ACTIVITY. THESE FINDINGS INDICATE THAT BOLDO IMPROVES VASCULAR AND MUSCLE INTEGRITY, SUPPORTING ITS POTENTIAL AS A COMPLEMENTARY THERAPEUTIC STRATEGY FOR DYSFERLINOPATHY.
dc.formatapplication/pdf
dc.identifier.doi10.3390/ijms26209945
dc.identifier.issn1422-0067
dc.identifier.issn1422-0067
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/14377
dc.languageENG
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
dc.relation.uri10.3390/ijms26209945
dc.rightsOPEN ACCESS
dc.subjectDysferlinopathy
dc.subjectPeumus boldus
dc.subjectSkeletal muscle
dc.titleBOLDO RESTORES VASCULARIZATION AND REDUCES SKELETAL MUSCLE INFLAMMATION IN SYMPTOMATIC MICE WITH DYSFERLINOPATHY
dc.typeARTÍCULO
dspace.entity.typePublication
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceUBB- UNIVERSIDAD DEL BÍO-BÍO
oaire.licenseConditionCC BY 4.0
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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