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CIRCADIAN SYSTEM AND MELATONIN HORMONE: RISK FACTOR FOR COMPLICATIONS DURING PREGNANCY

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dc.creatorJEANNETTE MARISOL VERA ARAYA
dc.creatorFRANCISCO JAVIER VALENZUELA MELGAREJO
dc.date2015
dc.date.accessioned2025-01-10T14:34:06Z
dc.date.available2025-01-10T14:34:06Z
dc.date.issued2015
dc.description.abstractPREGNANCY IS A COMPLEX AND WELL-REGULATED TEMPORAL EVENT IN WHICH SEVERAL STEPS ARE FINELY ORCHESTRATED INCLUDING IMPLANTATION, DECIDUALIZATION, PLACENTATION, AND PARTUM AND ANY TEMPORARY ALTERATION HAS SERIOUS EFFECTS ON FETAL AND MATERNAL HEALTH. INTERESTINGLY, ALTERATIONS OF CIRCADIAN RHYTHMS (I.E., SHIFTWORK) HAVE BEEN CORRELATED WITH INCREASED RISK OF PRETERM DELIVERY, INTRAUTERINE GROWTH RESTRICTION, AND PREECLAMPSIA. IN THE LAST FEW YEARS EVIDENCE IS ACCUMULATING THAT THE PLACENTA MAY HAVE A FUNCTIONAL CIRCADIAN SYSTEM AND EXPRESS THE CLOCK GENES BMAL1, PER1-2, AND CLOCK. ON THE OTHER HAND, THERE IS EVIDENCE THAT THE HUMAN PLACENTA SYNTHESIZES MELATONIN, HORMONE INVOLVED IN THE REGULATION OF THE CIRCADIAN SYSTEM IN OTHER TISSUES. MOREOVER, IS UNKNOWN THE ROLE OF THIS LOCAL PRODUCTION OF MELATONIN AND WHETHER THIS PRODUCTION HAVE A CIRCADIAN PATTERN. AVAILABLE INFORMATION INDICATES THAT MELATONIN INDUCES IN PLACENTA THE EXPRESSION OF ANTIOXIDANT ENZYMES CATALASE AND SUPEROXIDE DISMUTASE, PREVENTS THE INJURY PRODUCED BY OXIDATIVE STRESS, AND INHIBITS THE EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) A GENE THAT IN OTHER TISSUES IS CONTROLLED BY CLOCK GENES. IN THIS REVIEW WE AIM TO ANALYZE AVAILABLE INFORMATION REGARDING CLOCK GENES AND CLOCK GENES CONTROLLED GENES SUCH AS VEGF AND THE POSSIBLE ROLE OF MELATONIN SYNTHESIS IN THE PLACENTA.
dc.formatapplication/pdf
dc.identifier.doi10.1155/2015/825802
dc.identifier.issn1687-9589
dc.identifier.issn1687-9597
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/7994
dc.languagespa
dc.publisherOBSTRETRICS AND GYNECOLOGY INTERNATIONAL
dc.relation.uri10.1155/2015/825802
dc.rightsPUBLICADA
dc.titleCIRCADIAN SYSTEM AND MELATONIN HORMONE: RISK FACTOR FOR COMPLICATIONS DURING PREGNANCY
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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