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INVASIVE DIATOM DIDYMOSPHENIA GEMINATA AS A SOURCE OF POLYSACCHARIDES WITH ANTIOXIDANT AND IMMUNOMODULATORY EFFECTS ON MACROPHAGE CELL LINES

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dc.creatorJAIME ROBERTO CABRERA PARDO
dc.date2020
dc.date.accessioned2025-01-10T15:13:17Z
dc.date.available2025-01-10T15:13:17Z
dc.date.issued2020
dc.description.abstractTHIS STUDY ADDRESSES FOR THE FIRST TIME THE CHEMISTRY AND BIOLOGICAL ACTIVITY OF POLYSACCHARIDES ISOLATED FROM DIDYMOSPHENIA GEMINATA. FOURIER-TRANSFORM INFRARED SPECTROSCOPY (FTIR) AND HIGH-PERFORMANCE THIN-LAYER CHROMATOGRAPHY (HPTLC) TECHNIQUES WERE USED TO CHARACTERIZE THE CRUDE AND ACIDIC POLYSACCHARIDES OF D. GEMINATA; GALACTOSE AND XYLOSE WERE FOUND TO BE THE MAIN MONOMER COMPONENTS. THE ANTIOXIDANT ACTIVITY AS WELL AS THE EFFECT ON THE EXPRESSION OF IL-6 AND TNF-? IN RAW 264.7 MURINE CELL LINES WERE DETERMINED FOR BOTH TYPES OF POLYSACCHARIDES. THE ANTIOXIDANT ACTIVITY OF CRUDE POLYSACCHARIDES PROVED TO BE STRONGER THAN ACIDIC POLYSACCHARIDES BY MEANS OF QUENCHING EXPERIMENTS OF ABTS·+ AND TROLOX EQUIVALENT ANTIOXIDANT CAPACITY (TEAC) (P < 0.05). CRUDE POLYSACCHARIDES INDUCED AN INCREASE IN BOTH IL-6 AND TNF-? CONTENTS. ACIDIC POLYSACCHARIDES PRODUCED A SIMILAR EFFECT ON THESE CYTOKINES, BUT TO A LESSER EXTENT. THESE RESULTS SUGGEST THAT POLYSACCHARIDES FROM D. GEMINATA COULD BE EXPLORED AS NATURAL ANTIOXIDANT AND IMMUNOMODULATORY AGENTS IN MEDICINE AND THE NUTRACEUTICAL INDUSTRY. THIS INVESTIGATION SUGGESTS AN OPPORTUNITY TO TURN THE INVASIVE MATS OF D. GEMINATA, WHICH CURRENTLY CAUSE ENVIRONMENTAL PROBLEMS, INTO A SOURCE OF POLYSACCHARIDES WITH NUTRACEUTICAL APPLICATION.
dc.formatapplication/pdf
dc.identifier.doi10.1007/s10811-019-01976-6
dc.identifier.issn1573-5176
dc.identifier.issn0921-8971
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/10988
dc.languagespa
dc.publisherJOURNAL OF APPLIED PHYCOLOGY
dc.relation.uri10.1007/s10811-019-01976-6
dc.rightsPUBLICADA
dc.titleINVASIVE DIATOM DIDYMOSPHENIA GEMINATA AS A SOURCE OF POLYSACCHARIDES WITH ANTIOXIDANT AND IMMUNOMODULATORY EFFECTS ON MACROPHAGE CELL LINES
dc.title.alternativeDIATOMEA INVASIVA DIDYMOSPHENIA GEMINATA COMO FUENTE DE POLISACÁRIDOS CON EFECTOS ANTIOXIDANTES E INMUNOMODULADORES SOBRE LÍNEAS CELULARES DE MACRÓFAGOS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE QUIMICA
ubb.SedeCONCEPCIÓN
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