Publicación: ARE ASSOCIATIONS BETWEEN ADHERENCE TO THE 2018 WCRF/AICR CANCER PREVENTION RECOMMENDATIONS AND RISK OF CANCERS MODULATED BY MULTIMORBIDITY? FINDINGS FROM THE UK BIOBANK PROSPECTIVE COHORT STUDY
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2024
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PROCEEDINGS OF THE NUTRITION SOCIETY
Resumen
APPROXIMATELY 40% OF CANCERS IN THE UK ARE ATTRIBUTABLE TO MODIFIABLE, LIFESTYLE RISK FACTORS SUCH AS OVERWEIGHT AND OBESITY AND LOW DIETARY FIBRE INTAKE(1). THE WCRF AND AICR PUBLISHED TEN LIFESTYLE- BASED CANCER PREVENTION RECOMMENDATIONS WITH THE AIM OF REDUCING THE RISK OF CANCER AND OTHER NON-COMMUNICABLE DISEASES(2). IN THE UK BIOBANK COHORT, WE HAVE FOUND REDUCED RISK OF CANCER OVERALL AND OF BREAST AND COLORECTAL CANCERS WITH GREATER ADHERENCE TO THESE CANCER PREVENTION RECOMMENDATIONS (I.E., HEALTHIER LIFESTYLES). THE PRESENT STUDY AIMED TO INVESTIGATE WHETHER THE MAGNITUDE OF THESE ASSOCIATIONS IS MODIFIED BY THE PRESENCE OF CO-MORBIDITIES, SUCH AS DIABETES AND CARDIOVASCULAR DISEASE, AT BASELINE.
WE USED DATA FROM 94,778 PARTICIPANTS (53% FEMALE, MEAN AGE 56 YEARS) FROM THE UK BIOBANK PROSPECTIVE COHORT STUDY, RECRUITED BETWEEN 2006 AND 2010 AND FREE FROM CANCER AT BASELINE. ADHERENCE TO THE 2018 WCRF/AICR CANCER PREVENTION RECOMMENDATIONS WAS CALCULATED FROM DIETARY, PHYSICAL ACTIVITY, AND BODY COMPOSITION DATA USING A STANDARDISED SCORE(3). MULTIMORBIDITY (LIST OF 43 CHRONIC DISEASES) WAS SELF-REPORTED AT BASELINE AND CATEGORISED INTO: 0, 1, 2, OR 3+ CHRONIC ILLNESSES. INCIDENT CANCER CASES WERE IDENTIFIED USING POPULATION-BASED CANCER REGISTRIES AVAILABLE UNTIL JULY 2019 FOR ENGLAND AND WALES AND OCTOBER 2015 FOR SCOTLAND. PARTICIPANTS WERE CATEGORISED INTO APPROXIMATE SCORE TERTILES, AND THE LOWEST TERTILE (LOWEST ADHERENCE, 0-3.5 POINTS) WAS USED AS THE REFERENCE CATEGORY. COX PROPORTIONAL HAZARD MODELS WERE USED TO INVESTIGATE ASSOCIATIONS BETWEEN TOTAL SCORE AND INCIDENCE OF CANCER, ADJUSTING FOR CONFOUNDERS, AND TO TEST FOR AN INTERACTION BETWEEN TOTAL SCORE AND MULTIMORBIDITY.
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risk of cancer, multimorbidity, cancer
