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ANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF CHICHIPEGENIN, PENIOCEROL, AND MACDOUGALLIN ISOLATED FROM MYRTILLOCACTUS GEOMETRIZANS (MART. EX PFEIFF.) CON.

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dc.creatorCARLOS LEONARDO ARMANDO CÉSPEDES ACUÑA
dc.date2011
dc.date.accessioned2025-01-10T14:31:51Z
dc.date.available2025-01-10T14:31:51Z
dc.date.issued2011
dc.description.abstractTHE OLEANANE-TYPE TRITERPENE CHICHIPEGENIN AND THE STEROLS PENIOCEROL AND MACDOUGALLIN, ISOLATED FROM MYRTILLOCACTUS GEOMETRIZANS, SHOWED ANTI-INFLAMMATORY ACTIVITIES IN BOTH THE 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA)-INDUCED MOUSE EAR EDEMA MODEL AND THE CARRAGEENAN-INDUCED RAT PAW EDEMA MODEL. ALL TESTED COMPOUNDS INHIBITED THE TPA-INDUCED EDEMA IN A DOSE-DEPENDENT MANNER, WITH ED50 VALUES LESS THAN OR EQUAL TO THAT SHOWN BY INDOMETHACIN. AMONG THEM, PENIOCEROL WAS THE MOST ACTIVE COMPOUND. HOWEVER, ONLY PENIOCEROL AND MACDOUGALLIN REDUCED CARRAGEENAN-INDUCED RAT PAW EDEMA. ON THE OTHER HAND, PENIOCEROL AND MACDOUGALLIN SHOWED CYTOTOXICITY AGAINST SEVERAL HUMAN CANCER CELL LINES. THESE RESULTS INDICATE THAT COMPOUNDS ISOLATED FROM M. GEOMETRIZANS POSSESS ANTIINFLAMMATORY AND CYTOTOXIC PROPERTIES, AND THE PRESENCE OF CHICHIPEGENIN IN THE AERIAL PARTS COULD JUSTIFY THE MEDICINAL USES ATTRIBUTED TO THE PLANT.
dc.formatapplication/pdf
dc.identifier.issn0939-5075
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/7833
dc.languagespa
dc.publisherZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
dc.rightsPUBLICADA
dc.titleANTI-INFLAMMATORY AND CYTOTOXIC ACTIVITIES OF CHICHIPEGENIN, PENIOCEROL, AND MACDOUGALLIN ISOLATED FROM MYRTILLOCACTUS GEOMETRIZANS (MART. EX PFEIFF.) CON.
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
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