Publicación: NATURAL COMPOUNDS PURIFIED FROM THE LEAVES OF ARISTOTELIA CHILENSIS: MAKOMAKINOL, A NEW ALKALOID AND THE EFFECT OF ARISTOTELINE AND HOBARTINE ON NAV CHANNELS
| dc.creator | JAIME ROBERTO CABRERA PARDO | |
| dc.date | 2023 | |
| dc.date.accessioned | 2025-01-10T15:41:37Z | |
| dc.date.available | 2025-01-10T15:41:37Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | ARISTOTELIA CHILENSIS OR MAQUI IS A TREE NATIVE TO CHILE USED IN THE FOLK MEDICINE OF THE MAPUCHE PEOPLE AS AN ANTI-INFLAMMATORY AGENT FOR THE TREATMENT OF DIGESTIVE AILMENTS, FEVER, AND SKIN LESIONS. MAQUI FRUITS ARE BLACK BERRIES WHICH ARE CONSIDERED A ?SUPERFRUIT? WITH NOTABLE POTENTIAL HEALTH BENEFITS, PROMOTED TO BE AN ANTIOXIDANT, CARDIOPROTECTIVE, AND ANTI-INFLAMMATORY. MAQUI LEAVES CONTAIN NON-IRIDOID MONOTERPENE INDOLE ALKALOIDS WHICH HAVE PREVIOUSLY BEEN SHOWN TO ACT ON NICOTINIC ACETYLCHOLINE RECEPTORS, POTASSIUM CHANNELS, AND CALCIUM CHANNELS. HERE, WE ISOLATED A NEW ALKALOID FROM MAQUI LEAVES, NOW CALLED MAKOMAKINOL, TOGETHER WITH THE KNOWN ALKALOIDS ARISTOTELINE, HOBARTINE, AND 3-FORMYLINDOLE. MOREOVER, THE POLYPHENOLS QUERCETINE, ETHYL CAFFEATE, AND THE TERPENES, DIHYDRO-?-IONONE AND TERPIN HYDRATE, WERE ALSO OBTAINED. IN LIGHT OF THE REPORTED ANALGESIC AND ANTI-NOCICEPTIVE PROPERTIES OF A. CHILENSIS, IN PARTICULAR A CRUDE MIXTURE OF ALKALOIDS CONTAINING ARISTOTELINE AND HOBARTINOL (PMID 21585384), WE THEREFORE EVALUATED THE ACTIVITY OF ARISTOTELINE AND HOBARTINE ON NAV1.8, A KEY NAV ISOFORM INVOLVED IN NOCICEPTION, USING AUTOMATED WHOLE-CELL PATCH-CLAMP ELECTROPHYSIOLOGY. ARISTOTELINE AND HOBARTINE BOTH INHIBITED NAV1.8 WITH AN IC50 OF 68 ± 3 ?M AND 54 ± 1 ?M, RESPECTIVELY. HOBARTINE CAUSED A HYPERPOLARIZING SHIFT OF THE VOLTAGE-DEPENDENCE OF THE ACTIVATION, WHEREAS ARISTOTELINE DID NOT CHANGE THE VOLTAGE-DEPENDENCE OF THE ACTIVATION OR INACTIVATION. THE INHIBITORY ACTIVITY OF THESE ALKALOIDS ON NAV CHANNELS MAY CONTRIBUTE TO THE REPORTED ANALGESIC PROPERTIES OF ARISTOTELIA CHILENSIS USED BY THE MAPUCHE PEOPLE. | |
| dc.format | application/pdf | |
| dc.identifier.doi | 10.3390/ijms242115504 | |
| dc.identifier.issn | 1422-0067 | |
| dc.identifier.issn | 1422-0067 | |
| dc.identifier.uri | https://repositorio.ubiobio.cl/handle/123456789/13217 | |
| dc.language | spa | |
| dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | |
| dc.relation.uri | 10.3390/ijms242115504 | |
| dc.rights | PUBLICADA | |
| dc.subject | NaV1.8 | |
| dc.subject | makomakinol | |
| dc.subject | indole alkaloids | |
| dc.subject | hobartine | |
| dc.subject | aristoteline | |
| dc.subject | Aristotelia chilensis | |
| dc.title | NATURAL COMPOUNDS PURIFIED FROM THE LEAVES OF ARISTOTELIA CHILENSIS: MAKOMAKINOL, A NEW ALKALOID AND THE EFFECT OF ARISTOTELINE AND HOBARTINE ON NAV CHANNELS | |
| dc.type | ARTÍCULO | |
| dspace.entity.type | Publication | |
| ubb.Estado | PUBLICADA | |
| ubb.Otra Reparticion | DEPARTAMENTO DE QUIMICA | |
| ubb.Sede | CONCEPCIÓN |
