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MELATONIN INHIBITS THE CHANGE OF HMG-COA REDUCTASE AND SREBP INDUCED BY FRUCTOSE IN THE LIVER OF NEWBORN. PRELIMINARY RESULTS.

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dc.creatorFABIOLA CONSTANZA CARMONA PASTÉN
dc.creatorGUSTAVO ADOLFO DELGADO SANDOVAL
dc.creatorFRANCISCO JAVIER VALENZUELA MELGAREJO
dc.creatorCLAUDIA ANDREA CARO DÍAZ
dc.date2019
dc.date.accessioned2025-01-10T15:12:18Z
dc.date.available2025-01-10T15:12:18Z
dc.date.issued2019
dc.description.abstractINHIBITION OF MELATONIN PRODUCTION DURING NIGHT HOURS INCREASES THE IMPAIRMENT OF METABOLISM, ELEVATING THE RISK OF OBESITY, HYPERGLYCEMIA, AND DYSLIPIDEMIA DURING PREGNANCY. FRUCTOSE CONSUMPTION HAS DETRIMENTAL EFFECTS OVER METABOLISM AND THE CIRCADIAN SYSTEM. SEVERAL REPORTS SUGGEST THAT MELATONIN HAS A PROTECTOR ROLE DURING THE PREGNANCY BY THEIR ANTIOXIDANT/CHRONOBIOTIC PROPERTIES, AND FROM THE ABOVE, WE SPECULATES TO MELATONIN CAN BE REVERTING THE CHRONODISRUPTION AND ELEVATION OF MASTER REGULATORS OF LIPID METABOLISM IN THE NEWBORN. MEASURE IN THE LIVER OF NEWBORN THE MRNA EXPRESSION OF CLOCK-GENE BMAL-1, HMG-COA REDUCTASE, SREBP AND THE CLOCK-CONTROLLED GENE WEE-1 OF THE NEWBORN FROM MOTHER TREATED WITH FRUCTOSE AND MELATONIN.
dc.formatapplication/pdf
dc.identifier.doi10.1016/j.placenta.2019.06.297
dc.identifier.issn1532-3102
dc.identifier.issn0143-4004
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/10911
dc.languagespa
dc.publisherPLACENTA
dc.relation.uri10.1016/j.placenta.2019.06.297
dc.rightsPUBLICADA
dc.titleMELATONIN INHIBITS THE CHANGE OF HMG-COA REDUCTASE AND SREBP INDUCED BY FRUCTOSE IN THE LIVER OF NEWBORN. PRELIMINARY RESULTS.
dc.title.alternativeLA MELATONINA INHIBE EL CAMBIO DE HMG-COA REDUCTASA Y SREBP INDUCIDO POR LA FRUCTOSA EN EL HÍGADO DEL RECIÉN NACIDO. RESULTADOS PRELIMINARES.
dc.typeMEETING ABSTRACT
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionRECTORIA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCONCEPCIÓN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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