Publicación:
ABBREVIATED SCORE TO ASSESS ADHERENCE TO THE 2018 WCRF/AICR CANCER PREVENTION RECOMMENDATIONS AND RISK OF CANCER IN THE UK BIOBANK

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dc.creatorSOLANGE LILIANA PARRA SOTO
dc.date2024
dc.date.accessioned2025-01-10T15:44:18Z
dc.date.available2025-01-10T15:44:18Z
dc.date.issued2024
dc.description.abstractBACKGROUND: THE WORLD CANCER RESEARCH FUND (WCRF)/AMERICAN INSTITUTE FOR CANCER RESEARCH (AICR) CANCER PREVENTION RECOMMENDATIONS ARE LIFESTYLE-BASED GUIDELINES WHICH AIM TO REDUCE CANCER RISK. THIS STUDY INVESTIGATED, IN THE UK BIOBANK, ASSOCIATIONS BETWEEN AN ABBREVIATED SCORE TO ASSESS ADHERENCE TO THESE RECOMMENDATIONS AND THE RISK OF ALL CANCERS COMBINED AND OF 14 CANCERS FOR WHICH THERE IS STRONG EVIDENCE FOR LINKS WITH DIET, ADIPOSITY, AND PHYSICAL ACTIVITY. METHODS: WE USED DATA FROM 288,802 UK BIOBANK PARTICIPANTS (MEAN AGE 56.2 YEARS), CANCER-FREE AT BASELINE. AN ABBREVIATED VERSION OF THE 2018 WCRF/AICR SCORE WAS CALCULATED TO ASSESS ADHERENCE TO FIVE RECOMMENDATIONS ON (I) BODY WEIGHT, (II) PHYSICAL ACTIVITY, (III) FRUITS, VEGETABLES, AND DIETARY FIBER, (IV) RED AND PROCESSED MEAT, AND (V) ALCOHOL. MULTIVARIABLE COX PROPORTIONAL HAZARDS MODELS WERE USED TO ANALYZE ASSOCIATIONS BETWEEN THE ABBREVIATED SCORE (RANGE, 0-5 POINTS) AND CANCER INCIDENCE, ADJUSTING FOR CONFOUNDERS. RESULTS: DURING A MEDIAN FOLLOW-UP OF 8.2 YEARS (INTERQUARTILE RANGE, 7.4-8.9), 23,448 PARTICIPANTS WERE DIAGNOSED WITH CANCER. THE ABBREVIATED SCORE WAS INVERSELY ASSOCIATED WITH RISK OF CANCER OVERALL [HR: 0.93; 95% CONFIDENCE INTERVAL (CI): 0.92-0.95 PER 1-POINT INCREMENT], AND BREAST (HR: 0.90; 95% CI: 0.87-0.94), COLORECTAL (HR: 0.86; 95% CI: 0.83-0.90), LUNG (HR: 0.89; 95% CI: 0.84-0.94), KIDNEY (HR: 0.83; 95% CI: 0.76-0.90), PANCREATIC (HR: 0.86; 95% CI: 0.79-0.94), UTERINE (HR: 0.79; 95% CI: 0.73-0.86), ESOPHAGEAL (HR: 0.82; 95% CI: 0.75-0.90), STOMACH (HR: 0.89; 95% CI: 0.79-0.99), AND LIVER (HR: 0.80; 95% CI: 0.72-0.90) CANCERS. CONCLUSIONS: GREATER ADHERENCE TO THE CANCER PREVENTION RECOMMENDATIONS, ASSESSED USING AN ABBREVIATED SCORE, WAS ASSOCIATED WITH REDUCED RISK OF ALL CANCERS COMBINED AND OF NINE SITE-SPECIFIC CANCERS.
dc.formatapplication/pdf
dc.identifier.doi10.1158/1055-9965.EPI-23-0923
dc.identifier.issn1538-7755
dc.identifier.issn1055-9965
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/13426
dc.languagespa
dc.publisherCANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
dc.relation.uri10.1158/1055-9965.EPI-23-0923
dc.rightsPUBLICADA
dc.titleABBREVIATED SCORE TO ASSESS ADHERENCE TO THE 2018 WCRF/AICR CANCER PREVENTION RECOMMENDATIONS AND RISK OF CANCER IN THE UK BIOBANK
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE NUTRICION Y SALUD PUBLICA
ubb.SedeCHILLÁN
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