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CENTRIFUGAL PARTITION CHROMATOGRAPHY IS A POWERFUL TOOL FOR THE ISOLATION OF ANTIBIOFILM QUANTUM CARBON DOTS SYNTHESIZED BY HYDROTHERMAL TREATMENT OF AVOCADO PEELS

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dc.creatorJULIO ENRIQUE ILDEFONSO ALARCÓN ENOS
dc.creatorEDGAR RAFAEL PASTENE NAVARRETE
dc.creatorSERGIO MIGUEL ACUÑA NELSON
dc.creatorGIRLENNE BERNARDITA CHRISTIANSEN ALVAREZ
dc.creatorMATÍAS IGNACIO VENEGAS TOLOZA
dc.creatorTATIANA BELDARRAÍN IZNAGA
dc.creatorDIANA ISABEL CORREA OTERO
dc.creatorNANDIS MAHELY FIALLOS MARAVILLA
dc.date2025
dc.date.accessioned2025-12-15T13:59:32Z
dc.date.available2025-12-15T13:59:32Z
dc.date.issued2025
dc.description.abstractCARBON QUANTUM DOTS (CQD) ARE AN EMERGENT NANOMATERIAL WITH UNIQUE OPTICAL AND BIOLOGICAL PROPERTIES. HOWEVER, THE PURIFICATION OF CQD IS ONE OF THE BOTTLENECKS THAT MAKES IT DIFFICULT TO SCALE FOR APPLICATION IN DIFFERENT AREAS. IN THIS WORK, WE EXPLORE FOR THE FIRST TIME THE POTENTIAL OF CENTRIFUGAL PARTITION CHROMATOGRAPHY (CPC) AS AN ALTERNATIVE PREPARATIVE TECHNOLOGY TO ACHIEVE THE PURIFICATION OF CQD AT THE GRAM SCALE. THE HYDROTHERMAL METHOD WAS USED TO SYNTHESIZE CQD FROM AVOCADO PEELS. AFTER 6 H AT 250 °C, A COMPLEX MIX OF STRONG BLUE-FLUORESCENT CQDS WERE OBTAINED AND SUBMITTED TO CPC FRACTIONATION WITHOUT PRETREATMENT. THE BEST RESULTS WERE OBTAINED WITH THE SOLVENT SYSTEM N-HEXANE?ETHYL ACETATE?METHANOL?WATER (1:2:1:2, V/V/V/V), IN AN ELUTION-EXTRUSION PROTOCOL. NINE FRACTIONS WERE OBTAINED AND WERE CHARACTERIZED BY UV-VIS SPECTROPHOTOMETRY, FOURIER TRANSFORM INFRARED (F-TIR), AND FIELD EMISSION SCANNING ELECTRON MICROSCOPY (FESEM), CONFIRMING THE PRESENCE OF CQD OF DIFFERENT SIZES. CPC FRACTIONATIONS INDICATE THAT A POLARITY-BASED SEPARATION MECHANISM CAN BE USED TO PURIFY CQD. INTERESTINGLY, FOUR FRACTIONS SHOWED ANTIBACTERIAL AND ANTI-BIOFILM EFFECTS ON PSEUDOMONAS PUTIDA AND LISTERIA MONOCYTOGENES. THEREFORE, CPC ALLOWS FOR BETTER REFINING OF THIS TYPE OF NANOMATERIAL, AND IN COMBINATION WITH OTHER TECHNIQUES, IT WOULD SERVE TO OBTAIN CQD OF HIGHER PURITY, FACILITATING THE PHYSICOCHEMICAL AND BIOACTIVITY CHARACTERIZATION OF THESE PARTICLES. CPC WOULD ALSO ALLOW THE USE OF WASTE, SUCH AS AVOCADO PEELS, TO OBTAIN NEW MATERIALS.
dc.formatapplication/pdf
dc.identifier.doi10.3390/molecules30071525
dc.identifier.issn1420-3049
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/14303
dc.language
dc.publisherMOLECULES
dc.relation.uri10.3390/molecules30071525
dc.rightsOPEN ACCESS
dc.subjectCentrifugal partition chromatography
dc.subjectCarbon quantum dots
dc.subjectAntimicrobials
dc.subjectBiofilms
dc.subjectAvocado
dc.titleCENTRIFUGAL PARTITION CHROMATOGRAPHY IS A POWERFUL TOOL FOR THE ISOLATION OF ANTIBIOFILM QUANTUM CARBON DOTS SYNTHESIZED BY HYDROTHERMAL TREATMENT OF AVOCADO PEELS
dc.typeARTÍCULO
dspace.entity.typePublication
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.fundingReferenceANID- AGENCIA NACIONAL DE INVESTIGACIÓN Y DESARROLLO (EX CONICYT)
oaire.licenseConditionCC BY 4.0
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN ALIMENTOS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionSUBDIRECCION DE INNOVACION
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN ALIMENTOS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionCARRERA INGENIERIA ESTADISTICA
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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ubb.SedeCONCEPCIÓN
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