Publicación:
DYHIDRO-B-AGAROFURANS NATURAL AND SYNTHETIC AS ACETYLCHOLINESTERASE AND COX INHIBITORS: INTERACTION WITH THE PERIPHERAL ANIONIC SITE (ACHEPAS), AND ANTI-INFLAMMATORY POTENTIALS

Vista sencilla de ítem
dc.creatorEVELYN DEL PILAR MUÑOZ NÚÑEZ
dc.creatorSOLEDAD MARGARITA QUIROZ CARREÑO
dc.creatorEDGAR RAFAEL PASTENE NAVARRETE
dc.creatorCARLOS LEONARDO ARMANDO CÉSPEDES ACUÑA
dc.creatorJULIO ENRIQUE ILDEFONSO ALARCÓN ENOS
dc.date2022
dc.date.accessioned2025-01-10T15:31:21Z
dc.date.available2025-01-10T15:31:21Z
dc.date.issued2022
dc.description.abstractIN ORDER TO FIND MOLECULES OF NATURAL ORIGIN WITH POTENTIAL BIOLOGICAL ACTIVITIES, WE ISOLATE AND SYNTHESISE COMPOUNDS WITH AGAROFURAN SKELETONS (EPOXYEUDESMANES). FROM THE SEEDS OF MAYTENUS DISTICHA AND MAYTENUS MAGELLANICA WE OBTAINED SIX DIHYDRO-?-AGAROFURANS, AND BY MEANS OF THE ROBINSON ANNULATION REACTION WE SYNTHESISED FIVE COMPOUNDS WITH THE SAME SKELETON. THE STRUCTURES WERE ESTABLISHED ON THE BASIS OF NMR, IR, AND MS. THE EVALUATED COMPOUNDS SHOWED INHIBITORY ACTIVITY ON THE ACETYLCHOLINESTERASE ENZYME AND ON THE COX ENZYMES. COMPOUND 4 EMERGED AS THE MOST POTENT IN THE ACETYLCHOLINESTERASE INHIBITION ASSAY WITH IC50 17.0 ± 0.016 ?M ON ACETYLCHOLINESTERASE (ACHE). THE COMPOUNDS EVALUATED WERE SHOWN TO BE SELECTIVE FOR ACHE. THE MOLECULAR DOCKING, AND THE PROPIDIUM DISPLACEMENT ASSAY SUGGESTED THAT THE COMPOUNDS DO NOT BIND TO THE ACTIVE SITE OF THE ENZYME ACHE, BUT RATHER BIND TO THE PERIPHERAL ANIONIC SITE (PAS) OF THE ENZYME, ON THE OTHER HAND, THE NATURAL COMPOUND 8, SHOWED THE BEST INHIBITORY ACTIVITY ON THE COX-2 ENZYME WITH AN IC50 VALUE OF 0.04 ± 0.007 ?M. THE PHARMACOKINETIC PROFILE CALCULATED IN SILICO USING THE SWISSADME PLATFORM SHOWS THAT THESE MOLECULES COULD BE CONSIDERED AS POTENTIAL DRUGS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES SUCH AS AD.
dc.formatapplication/pdf
dc.identifier.doi10.1080/14756366.2022.2091554
dc.identifier.issn1475-6374
dc.identifier.issn1475-6366
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/12414
dc.languagespa
dc.publisherJOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
dc.relation.uri10.1080/14756366.2022.2091554
dc.rightsPUBLICADA
dc.titleDYHIDRO-B-AGAROFURANS NATURAL AND SYNTHETIC AS ACETYLCHOLINESTERASE AND COX INHIBITORS: INTERACTION WITH THE PERIPHERAL ANIONIC SITE (ACHEPAS), AND ANTI-INFLAMMATORY POTENTIALS
dc.title.alternativeDYHIDRO-B-AGAROFURANOS NATURALES Y SINTÉTICOS COMO ACETILCOLINESTERASA E INHIBIDORES DE LA COX: INTERACCIÓN CON EL SITIO ANIÓNICO PERIFÉRICO (ACHE-PAS), Y POTENCIALES ANTIINFLAMATORIOS
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
Archivos
Colecciones
Artículos científicos