Publicación: BAUHINIA CANDICANS IMPROVES THE ENDOTHELIUM-DEPENDENT RELAXATION IN AORTIC RINGS OF ALLOXAN-DIABETIC RATS.
Fecha
2010
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Editor
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Resumen
BAHUINIA CANDICANS IS A PLANT USED IN CHILE FOR DIABETES MANAGEMENT. THE AIM OF THE PRESENT STUDY WAS TO INVESTIGATE THE RELAXING RESPONSIVENESS TO ACETYLCHOLINE (ACH) OF PHENYLEPHRINE-PRECONTRACTED AORTIC RINGS FROM ALLOXAN-DIABETIC RATS TREATED WITH AN AQUEOUS-ETHANOL EXTRACT OF B.CANDICANS LEAVES (EBC-RATS, 120 MG/KG/DAY). EBC SIGNIFICANTLY REDUCED FASTING BLOOD SUGAR FROM 292.4 ± 9.2 MG/DL TO 174.6 ± 12.8 MG/DL. ACH INDUCED A NEGLIGIBLE REDUCTION OF TENSION (28 ± 6%) OF AORTIC RINGS FROM ALX-RATS COMPARED WITH EBC-RATS (48 ± 5.5 %) AND NORMAL (57 ± 5 %). THE ENHANCED SENSITIVITY TO PHENYLEPHRINE IN AORTIC RINGS FROM DIABETIC RATS WAS REDUCED IN EBC-RATS. REMOVAL OF THE ENDOTHELIUM OR PRETREATMENT OF RINGS OF EBC-RATS WITH NITRIC OXIDE SYNTHASE (NOS) INHIBITOR, NG-NITRO-L-ARGININE METHYL ESTER (L-NAME) INCREASED THE PHE RESPONSE. THE NITRIC OXIDE (NO) DONOR SODIUM NITROPRUSSIDE (SNP) INDUCED A NORMAL RELAXATION IN THESE RINGS. THE RESULTS SUGGEST THAT THE EXTRACT OF LEAVES OF B. CANDICANS INCREASES ENDOTHELIUM-DEPENDENT RELAXATION OF AORTIC RINGS OF ALX-RATS AND ITS USE MAY BE HELPFUL IN THE PREVENTION OF DIABETIC COMPLICATIONS.
