Publicación: BINDING OF EBP50 TO NOX ORGANIZING SUBUNIT P47(PHOX) IS PIVOTAL TO CELLULAR REACTIVE SPECIES GENERATION AND ALTERED VASCULAR PHENOTYPE
| dc.creator | ANDRÉS IGNACIO RODRÍGUEZ MORALES | |
| dc.date | 2016 | |
| dc.date.accessioned | 2025-01-10T14:32:49Z | |
| dc.date.available | 2025-01-10T14:32:49Z | |
| dc.date.issued | 2016 | |
| dc.description.abstract | OUR FINDINGS IDENTIFY A PREVIOUSLY UNIDENTIFIED ROLE FOR SCAFFOLDING PROTEIN EZRIN-RADIXIN-MOESIN-BINDING PHOSPHOPROTEIN 50 (EBP50; AKA NHERF1) IN THE ACTIVATION OF NADPH OXIDASES (NOX), A FAMILY OF PROFESSIONAL REACTIVE OXYGEN SPECIES (ROS) PRODUCING ENZYMES IMPLICATED IN NUMEROUS PATHOLOGIES. WE DEMONSTRATE THAT EBP50 IS CRITICAL FOR AGONIST-INDUCED PRODUCTION OF ROS SUPEROXIDE ANION (O2??), AND THAT IT DIRECTLY ASSOCIATES WITH THE NOX ORGANIZING SUBUNIT P47PHOX. EBP50 DELETION ABOLISHES ANGIOTENSIN II-INDUCED CELLULAR HYPERTROPHY AND RESISTANCE ARTERY VASOCONSTRICTION. GIVEN THE WIDE ARRAY OF EBP50 CELLULAR INTERACTIONS AND THE UBIQUITY OF NOX, THE CURRENT FINDINGS SUPPORT A BROADER, MORE COMPLEX ORCHESTRATION OF NOX REGULATION THAN IS CURRENTLY HYPOTHESIZED. THE FINDINGS COULD AUGMENT FUTURE STRATEGIES TARGETING THIS INTERACTION IN DISEASE INVOLVING ABERRANT ROS, TISSUE REMODELING, AND/OR SMOOTH MUSCLE CONSTRICTION. | |
| dc.format | application/pdf | |
| dc.identifier.doi | 10.1073/pnas.1514161113 | |
| dc.identifier.issn | 0027-8424 | |
| dc.identifier.uri | https://repositorio.ubiobio.cl/handle/123456789/7904 | |
| dc.language | spa | |
| dc.publisher | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | |
| dc.relation.uri | 10.1073/pnas.1514161113 | |
| dc.rights | PUBLICADA | |
| dc.title | BINDING OF EBP50 TO NOX ORGANIZING SUBUNIT P47(PHOX) IS PIVOTAL TO CELLULAR REACTIVE SPECIES GENERATION AND ALTERED VASCULAR PHENOTYPE | |
| dc.type | ARTÍCULO | |
| dspace.entity.type | Publication | |
| ubb.Estado | PUBLICADA | |
| ubb.Otra Reparticion | DEPARTAMENTO DE CIENCIAS BASICAS | |
| ubb.Sede | CHILLÁN |
