Publicación: SOLUBILITY EFFECTS ON ANTIBACTERIAL ACTIVITY OF CHEMICALLY MODIFIED CHITOOLIGOSACCHARIDES OF FUNGAL ORIGIN
Fecha
2011
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Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
Resumen
CHITIN AND CHITOSAN ARE A CLASS OF METABOLITES THAT OCCURRING IN SOME FUNGI SPECIES THAT ARE ASSOCIATED WITH COMMERCIAL AND MEDICINAL PLANTS, THIS IS IN MUCOR SP. FOR EXAMPLE WITH AN AMPLE NUMBER OF BIOLOGICAL ACTIVITIES, BEING ANTIBACTERIAL AND ANTIFUNGAL ONE OF THE MOST IMPORTANT. INTO OUR PROGRAM OF SEARCH OF BIOPESTICIDES AND NATURAL COMPOUNDS WITH BIOLOGICAL ACTIVITIES, WE HAVE STUDYING CHITOSAN THAT WAS OBTAINED FROM THE CULTURE MEDIUM OF THE FUNGUS MUCOR RUOXII. CHITOOLIGOSACCHARIDES WERE PREPARED BY PARTIAL ACID HYDROLYSIS OF NATIVE CHITOSAN AND AN AMINOGLYCOSYLATED DERIVATIVE WAS OBTAINED BY REDUCTIVE AMINATION OF THE CHITOOLIGOSACCARIDE. THE SOLUBILITIES OF THESE COMPOUNDS WERE MEASURED AT DIFFERENT PHS AND ITS ANTIBACTERIAL ACTIVITY AGAINST ESCHERICHIA COLI (GRAM-NEGATIVE) AND STAPHYLOCOCCUS AUREUS (GRAM-POSITIVE). CHITOSAN AND THE DERIVATIVES TESTED EXHIBITED A GOOD ANTIBACTERIAL ACTIVITY AGAINST S. AUREUS.
