Publicación:
ARE THE COGNITIVE ALTERATIONS PRESENT IN CHILDREN BORN FROM PREECLAMPTIC PREGNANCIES THE RESULT OF IMPAIRED ANGIOGENESIS FOCUS ON THE POTENTIAL ROLE OF THE VEGF FAMILY.

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dc.creatorJESENIA MARIANELA ACURIO JÁCOME
dc.creatorEVELYN ELIA LARA NAVARRETE
dc.creatorCARLOS ALONSO ESCUDERO OROZCO
dc.date2018
dc.date.accessioned2025-01-10T15:02:11Z
dc.date.available2025-01-10T15:02:11Z
dc.date.issued2018
dc.description.abstractEVIDENCE FROM CLINICAL STUDIES HAS PROPOSED THAT CHILDREN BORN FROM PREECLAMPTIC WOMEN HAVE A HIGHER RISK OF SUFFERING NEUROLOGICAL, PSYCHOLOGICAL, OR BEHAVIORAL ALTERATIONS. HOWEVER, TO DATE, THE MECHANISMS BEHIND THESE OUTCOMES ARE POORLY UNDERSTOOD. HERE, WE SPECULATE THAT THE NEURODEVELOPMENTAL ALTERATIONS IN THE CHILDREN OF PREECLAMPTIC PREGNANCIES RESULT FROM IMPAIRED ANGIOGENESIS. THE PRO-ANGIOGENIC FACTORS VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AND PLACENTAL GROWTH FACTOR (PLGF) ARE KEY REGULATORS OF BOTH VASCULAR AND NEUROLOGICAL DEVELOPMENT, AND IT HAS BEEN WIDELY DEMONSTRATED THAT UMBILICAL BLOOD OF PREECLAMPTIC PREGNANCIES CONTAINS HIGH LEVELS OF SOLUBLE VEGF RECEPTOR TYPE 1 (SFLT-1), A DECOY RECEPTOR OF VEGF. AS A CONSEQUENCE, THIS ANTI-ANGIOGENIC STATE COULD LEAD TO LONG-LASTING NEUROLOGICAL OUTCOMES. IN THIS NON-SYSTEMATIC REVIEW, WE PROPOSE THAT ALTERATIONS IN THE CIRCULATING CONCENTRATIONS OF VEGF, PLGF, AND SFLT-1 IN PREECLAMPTIC PREGNANCIES WILL AFFECT BOTH FETAL CEREBROVASCULAR FUNCTION AND NEURODEVELOPMENT, WHICH IN TURN MAY CAUSE COGNITIVE ALTERATIONS IN POST-NATAL LIFE.
dc.formatapplication/pdf
dc.identifier.doi10.3389/fphys.2018.01591
dc.identifier.issn1664-042X
dc.identifier.issn1664-042X
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/10109
dc.languagespa
dc.publisherFrontiers in Physiology
dc.relation.uri10.3389/fphys.2018.01591
dc.rightsPUBLICADA
dc.titleARE THE COGNITIVE ALTERATIONS PRESENT IN CHILDREN BORN FROM PREECLAMPTIC PREGNANCIES THE RESULT OF IMPAIRED ANGIOGENESIS FOCUS ON THE POTENTIAL ROLE OF THE VEGF FAMILY.
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS DE REHABILITACION EN SALUD
ubb.Otra ReparticionGRUPOS DE INVESTIGACION
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCONCEPCIÓN
ubb.SedeCHILLÁN
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