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ABNORMAL CEREBRAL MICROVASCULAR PERFUSION AND REACTIVITY IN FEMALE OFFSPRING OF REDUCED UTERINE PERFUSION PRESSURE (RUPP) MICE MODEL

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dc.creatorNATHALY STEPHANIE RIVERA PAILAMILLA
dc.creatorEVELYN ELIA LARA NAVARRETE
dc.creatorCARLOS ALONSO ESCUDERO OROZCO
dc.date2022
dc.date.accessioned2025-01-10T15:32:09Z
dc.date.available2025-01-10T15:32:09Z
dc.date.issued2022
dc.description.abstractCHILDREN BORN FROM WOMEN WITH PREECLAMPSIA HAVE ALTERATIONS IN CEREBRAL NEUROVASCULAR DEVELOPMENT AND A HIGH RISK FOR DEVELOPING COGNITIVE ALTERATIONS. BECAUSE CEREBRAL BLOOD VESSELS ARE CRITICAL COMPONENTS IN CEREBROVASCULAR DEVELOPMENT, WE EVALUATED THE BRAIN MICROVASCULAR PERFUSION AND MICROVASCULAR REACTIVITY (EXPOSED TO EXTERNAL STIMULI OF WARM AND COLD) IN PUPS BORN TO PREECLAMPSIA-LIKE SYNDROME BASED ON THE REDUCTION OF UTERINE PERFUSION (RUPP). ALSO, WE EVALUATE THE ANGIOGENIC PROTEOMIC PROFILE IN THOSE BRAINS. PREGNANT MICE SHOWED A REDUCTION IN UTERINE FLOW AFTER RUPP SURGERY (-40 TO 50%) ASSOCIATED WITH UNFAVORABLE PERINATAL RESULTS COMPARED TO SHAM MICE. FURTHERMORE, OFFSPRING OF THE RUPP MICE EXHIBITED REDUCED BRAIN MICROVASCULAR PERFUSION AT POSTNATAL DAY 5 (P5) COMPARED WITH OFFSPRING FROM SHAM MICE. THIS REDUCTION WAS PREFERENTIALLY OBSERVED IN FEMALES. ALSO, BRAIN MICROVASCULAR REACTIVITY TO EXTERNAL STIMULI (WARM AND COLD) WAS REDUCED IN PUPS OF RUPP MICE. FURTHERMORE, A DIFFERENTIAL EXPRESSION OF THE ANGIOGENIC PROFILE ASSOCIATED WITH INFLAMMATION, EXTRINSIC APOPTOTIC, CANCER, AND CELLULAR SENESCENCE PROCESSES AS THE PRIMARY SIGNALING IMPAIRED PROCESS WAS FOUND IN THE BRAINS OF RUPP-OFFSPRING. THEN, OFFSPRING (P5) FROM PREECLAMPSIA-LIKE SYNDROME EXHIBIT IMPAIRED BRAIN PERFUSION AND MICROVASCULAR REACTIVITY, PARTICULARLY IN FEMALE MICE, ASSOCIATED WITH DIFFERENTIAL EXPRESSION OF ANGIOGENIC PROTEINS IN THE BRAIN TISSUE.
dc.formatapplication/pdf
dc.identifier.doi10.1177/0271678X221121872
dc.identifier.issn1559-7016
dc.identifier.issn0271-678X
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/12475
dc.languagespa
dc.publisherJOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
dc.relation.uri10.1177/0271678X221121872
dc.rightsPUBLICADA
dc.subjectPreeclampsia
dc.subjectplacental ischemia
dc.subjectneurodevelopment
dc.subjectcerebral perfusion
dc.subjectcerebral blood flow
dc.titleABNORMAL CEREBRAL MICROVASCULAR PERFUSION AND REACTIVITY IN FEMALE OFFSPRING OF REDUCED UTERINE PERFUSION PRESSURE (RUPP) MICE MODEL
dc.title.alternativePERFUSIÓN MICROVASCULAR CEREBRAL ANORMAL Y REACTIVIDAD EN DESCENDIENTES HEMBRAS DE RATONES CON PRESIÓN DE PERFUSIÓN UTERINA REDUCIDA (RUPP) MODELO
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionGRUPOS DE INVESTIGACION
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCONCEPCIÓN
ubb.SedeCHILLÁN
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