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FRACTIONATION AND HYDROLYZATION OF AVOCADO PEEL EXTRACT: IMPROVEMENT OF ANTIBACTERIAL ACTIVITY

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dc.creatorNIDIA CASAS FORERO
dc.creatorIGOR ALFONSO TRUJILLO MAYOL
dc.creatorFABIANA LIMA SILVA
dc.creatorEDGAR RAFAEL PASTENE NAVARRETE
dc.creatorJULIO ENRIQUE ILDEFONSO ALARCÓN ENOS
dc.date2021
dc.date.accessioned2025-01-10T15:24:48Z
dc.date.available2025-01-10T15:24:48Z
dc.date.issued2021
dc.description.abstractAVOCADO HASS (PERSEA AMERICANA MILL) PEEL EXTRACT (APE) HAS THE POTENTIAL AS A NATURAL INGREDIENT TO SUBSTITUTE FOR CHEMICAL PRESERVATIVES. THE OBJECTIVES OF THIS STUDY WERE TO ASSESS THE PHYTOCHEMICAL COMPOSITION BY HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY?QUADRUPOLE TIME-OF-FLIGHT MASS/MASS SPECTROMETRY (HPLC-QTOF-MS/MS), TOTAL PHENOLIC CONTENT (TPC), PROANTHOCYANIDIN (PAC) CONTENT, AND ANTIOXIDANT ACTIVITY OF THE APE, THE ORGANIC FRACTION (OF), THE AQUEOUS FRACTION (AF), AND THE ACID-MICROWAVE HYDROLYZED APE (HAPE), ON THE ANTIBACTERIAL ACTIVITY (ABA). THE RESULTS INDICATED THAT APE AND OF CONTAINED (P ? 0.05) A HIGHER PHENOLIC COMPOSITION AND ANTIOXIDANT ACTIVITY THAN AF AND HAPE. THE ABA SPECIFIED THAT PSEUDOMONAS AERUGINOSA AND BACILLUS CEREUS WERE INHIBITED BY ALL THE EXTRACTS (MINIMAL INHIBITORY CONCENTRATION?MIC ? 500 ?G/ML), STAPHYLOCOCCUS AUREUS WAS ONLY SIGNIFICANTLY INHIBITED BY APE (?750 ?G/ML), THE SAME MIC WAS OBSERVED FOR THE OF ON SALMONELLA SPP. AND LISTERIA MONOCYTOGENES. THE HAPE INCREASED THE INHIBITORY EFFICIENCY UP TO 25% ON ESCHERICHIA COLI AND SALMONELLA SPP. (MIC ? 750 ?G/ML), AND 83.34% ON L. MONOCYTOGENES (MIC ? 125 ?G/ML) COMPARED TO APE (MIC ? 750 ?G/ML). ALSO, HAPE INHIBITED THE BIOFILM FORMATION AT THE LOWEST CONCENTRATION (125 ?G/ML); MEANWHILE, THE BIOFILM DISRUPTION SHOWED TO BE CONCENTRATION-TIME-DEPENDENT (P ? 0.05) COMPARED TO AMOXICILLIN. IN CONCLUSION, THE FRACTIONATION AND HYDROLYZATION OF APE IMPROVED THE ABA; THUS, THOSE STRATEGIES ARE USEFUL TO DESIGN NEW ANTIMICROBIAL COMPOUNDS.
dc.formatapplication/pdf
dc.identifier.doi10.3390/antibiotics10010023
dc.identifier.issn2079-6382
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/11897
dc.languagespa
dc.publisherANTIBIOTICS-BASEL
dc.relation.uri10.3390/antibiotics10010023
dc.rightsPUBLICADA
dc.titleFRACTIONATION AND HYDROLYZATION OF AVOCADO PEEL EXTRACT: IMPROVEMENT OF ANTIBACTERIAL ACTIVITY
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN ALIMENTOS
ubb.Otra ReparticionDEPARTAMENTO DE INGENIERIA EN ALIMENTOS
ubb.Otra ReparticionRECTORIA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCONCEPCIÓN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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