Publicación: INSECTICIDAL, ANTIFEEDANT AND ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF SESQUITERPENOIDS DERIVED FROM EUDESMANE, THEIR MOLECULAR DOCKING AND QSAR
Fecha
2024
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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
Resumen
THIS WORK EVALUATED THE INSECTICIDAL, ANTIFEEDANT AND ACHE INHIBITORY ACTIVITY OF COMPOUNDS WITH EUDESMANE SKELETON. THE INSECTICIDAL ACTIVITY WAS TESTED AGAINST LARVAE OF DROSOPHILA MELANOGASTER AND CYDIA POMONELLA, THE COMPOUNDS 3 AND 4 WERE THE MOST ACTIVE (LC50 OF 104.2 AND 106.7 ?M; 82.0 AND 84.4 ?M, RESPECTIVELY). LIKEWISE, THE MENTIONED COMPOUNDS WERE THOSE THAT SHOWED THE HIGHEST ACETYLCHOLINESTERASE INHIBITORY ACTIVITY, WITH IC50 OF 0.26 ± 0.016 AND 0.77 ± 0.016 ?M, RESPECTIVELY.
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Palabras clave
QSAR, Insecticidal activity, Eudesmanolides, Dihydroagarofurans, Antifeedant activity, AChE
