Publicación: NEUROPROTECTIVE PROPERTIES OF EUDESMIN ON A CELLULAR MODEL OF AMYLOID-BETA PEPTIDE TOXICITY
Fecha
2023
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
JOURNAL OF ALZHEIMERS DISEASE
Resumen
ALZHEIMER'S DISEASE (AD) IS A NEURODEGENERATIVE DISORDER CHARACTERIZED BY PROGRESSIVE COGNITIVE IMPAIRMENT AND MEMORY LOSS. ONE OF THE HALLMARKS IN AD IS AMYLOID-? PEPTIDE (A?) ACCUMULATION, WHERE THE SOLUBLE OLIGOMERS OF A? (A?OS) ARE THE MOST TOXIC SPECIES, DETERIORATING THE SYNAPTIC FUNCTION, MEMBRANE INTEGRITY, AND NEURONAL STRUCTURES, WHICH ULTIMATELY LEAD TO APOPTOSIS. CURRENTLY, THERE ARE NO DRUGS TO ARREST AD PROGRESSION, AND CURRENT SCIENTIFIC EFFORTS ARE FOCUSED ON SEARCHING FOR NOVEL LEADS TO CONTROL THIS DISEASE. LIGNANS ARE COMPOUNDS EXTRACTED FROM CONIFERS AND HAVE SEVERAL MEDICINAL PROPERTIES. EUDESMIN (EU) IS AN EXTRACTABLE LIGNAN FROM THE WOOD OF ARAUCARIA ARAUCANA, A NATIVE TREE FROM CHILE. THIS METABOLITE HAS SHOWN A RANGE OF BIOLOGICAL PROPERTIES, INCLUDING THE ABILITY TO CONTROL INFLAMMATION AND ANTIBACTERIAL EFFECTS.
