Publicación:
NEUROPROTECTIVE PROPERTIES OF EUDESMIN ON A CELLULAR MODEL OF AMYLOID-BETA PEPTIDE TOXICITY

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dc.creatorJAIME ROBERTO CABRERA PARDO
dc.date2023
dc.date.accessioned2025-01-10T15:41:00Z
dc.date.available2025-01-10T15:41:00Z
dc.date.issued2023
dc.description.abstractALZHEIMER'S DISEASE (AD) IS A NEURODEGENERATIVE DISORDER CHARACTERIZED BY PROGRESSIVE COGNITIVE IMPAIRMENT AND MEMORY LOSS. ONE OF THE HALLMARKS IN AD IS AMYLOID-? PEPTIDE (A?) ACCUMULATION, WHERE THE SOLUBLE OLIGOMERS OF A? (A?OS) ARE THE MOST TOXIC SPECIES, DETERIORATING THE SYNAPTIC FUNCTION, MEMBRANE INTEGRITY, AND NEURONAL STRUCTURES, WHICH ULTIMATELY LEAD TO APOPTOSIS. CURRENTLY, THERE ARE NO DRUGS TO ARREST AD PROGRESSION, AND CURRENT SCIENTIFIC EFFORTS ARE FOCUSED ON SEARCHING FOR NOVEL LEADS TO CONTROL THIS DISEASE. LIGNANS ARE COMPOUNDS EXTRACTED FROM CONIFERS AND HAVE SEVERAL MEDICINAL PROPERTIES. EUDESMIN (EU) IS AN EXTRACTABLE LIGNAN FROM THE WOOD OF ARAUCARIA ARAUCANA, A NATIVE TREE FROM CHILE. THIS METABOLITE HAS SHOWN A RANGE OF BIOLOGICAL PROPERTIES, INCLUDING THE ABILITY TO CONTROL INFLAMMATION AND ANTIBACTERIAL EFFECTS.
dc.formatapplication/pdf
dc.identifier.doi10.3233/JAD-220935
dc.identifier.issn1875-8908
dc.identifier.issn1387-2877
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/13169
dc.languagespa
dc.publisherJOURNAL OF ALZHEIMERS DISEASE
dc.relation.uri10.3233/JAD-220935
dc.rightsPUBLICADA
dc.titleNEUROPROTECTIVE PROPERTIES OF EUDESMIN ON A CELLULAR MODEL OF AMYLOID-BETA PEPTIDE TOXICITY
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE QUIMICA
ubb.SedeCONCEPCIÓN
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