Publicación: EFFECT OF METAL IN SCHIFF BASES OF CHITOSAN ADSORBED ON GLASSY CARBON ELECTRODE IN THE INHIBITION OF SPHINGOMYELINASE C TOXIN.
Fecha
2018
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FOOD AND CHEMICAL TOXICOLOGY
Resumen
THIS STUDY WAS CONDUCTED TO ASSESS THE CATALYTIC ELECTRODE SURFACE ADSORPTION AND CAPTURE PROPERTIES OF DIFFERENT METAL CHITOSAN DERIVATIVES IN AQUEOUS PHOSPHATE BUFFER SOLUTION (PH?=?7.3). EARLY, RECENT WORK SHOWED THAT THE RESPONSE OF IRON CHITOSAN COMPLEX WITH R?=?-CH3 ON THE PERIPHERY, OVER BLOOD RED CELLS IN PRESENCE OF SPHINGOMYELINASE C WAS PROTECTED. THE EFFECT OF OTHERS SUBSTITUENT (R?=?-BR, -CL, -F, NO2, -OCH3, -H) ON THE PERIPHERY OF THE SCHIFF BASE LIGAND DID NOT SHOW CORRELATION WITH THE OXIDATION OF SPHINGOMYELINASE C AND ITS BIOLOGICAL RESPONSE. FOR THIS REASON, VARIOUS ADSORBED METAL (M?=?FE OF RECENT WORK, CU, NI AND CO) COMPLEXES OF CHITOSAN AND SCHIFF BASES ON GLASSY CARBON ELECTRODE FOR THE OXIDATION OF SPHINGOMYELINASE C WERE INVESTIGATED AND COMPARED, EACH ONE WITH -CH3 GROUP ON THE PERIPHERY OF THE SCHIFF BASE. UV?VIS AND IR-TF SPECTROSCOPIES, ELECTROCHEMISTRY AND MICROSCOPY ASSAY WERE PERFORMED; THEN, THE METAL EFFECT UNDERLYING. FOR THE SCHIFF BASE, COBALT AND COPPER COMPLEXES DID NOT PROVED TO BE A REMARKABLE CELLULAR PROTECTOR IN PRESENCE OF THE ENZYME, BUT THE NICKEL COMPLEX SHOWED TO BE A CELLULAR PROTECTOR AT SHORT TIME, THIS CONCLUSION HELP TO PROPOSAL A REACTION MECHANISM FOR THE ELECTROCHEMICAL AND BIOLOGICAL STUDIES.
