Publicación:
EFFECT OF METAL IN SCHIFF BASES OF CHITOSAN ADSORBED ON GLASSY CARBON ELECTRODE IN THE INHIBITION OF SPHINGOMYELINASE C TOXIN.

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dc.creatorFRANCISCO JAVIER VALENZUELA MELGAREJO
dc.creatorCLAUDIA ANDREA CARO DÍAZ
dc.creatorGERARDO ANDRÉS CABELLO GUZMÁN
dc.creatorLUIS ENRIQUE LILLO ARROYO
dc.date2018
dc.date.accessioned2025-01-10T15:02:29Z
dc.date.available2025-01-10T15:02:29Z
dc.date.issued2018
dc.description.abstractTHIS STUDY WAS CONDUCTED TO ASSESS THE CATALYTIC ELECTRODE SURFACE ADSORPTION AND CAPTURE PROPERTIES OF DIFFERENT METAL CHITOSAN DERIVATIVES IN AQUEOUS PHOSPHATE BUFFER SOLUTION (PH?=?7.3). EARLY, RECENT WORK SHOWED THAT THE RESPONSE OF IRON CHITOSAN COMPLEX WITH R?=?-CH3 ON THE PERIPHERY, OVER BLOOD RED CELLS IN PRESENCE OF SPHINGOMYELINASE C WAS PROTECTED. THE EFFECT OF OTHERS SUBSTITUENT (R?=?-BR, -CL, -F, NO2, -OCH3, -H) ON THE PERIPHERY OF THE SCHIFF BASE LIGAND DID NOT SHOW CORRELATION WITH THE OXIDATION OF SPHINGOMYELINASE C AND ITS BIOLOGICAL RESPONSE. FOR THIS REASON, VARIOUS ADSORBED METAL (M?=?FE OF RECENT WORK, CU, NI AND CO) COMPLEXES OF CHITOSAN AND SCHIFF BASES ON GLASSY CARBON ELECTRODE FOR THE OXIDATION OF SPHINGOMYELINASE C WERE INVESTIGATED AND COMPARED, EACH ONE WITH -CH3 GROUP ON THE PERIPHERY OF THE SCHIFF BASE. UV?VIS AND IR-TF SPECTROSCOPIES, ELECTROCHEMISTRY AND MICROSCOPY ASSAY WERE PERFORMED; THEN, THE METAL EFFECT UNDERLYING. FOR THE SCHIFF BASE, COBALT AND COPPER COMPLEXES DID NOT PROVED TO BE A REMARKABLE CELLULAR PROTECTOR IN PRESENCE OF THE ENZYME, BUT THE NICKEL COMPLEX SHOWED TO BE A CELLULAR PROTECTOR AT SHORT TIME, THIS CONCLUSION HELP TO PROPOSAL A REACTION MECHANISM FOR THE ELECTROCHEMICAL AND BIOLOGICAL STUDIES.
dc.formatapplication/pdf
dc.identifier.doi10.1016/j.fct.2018.07.055
dc.identifier.issn1873-6351
dc.identifier.issn0278-6915
dc.identifier.urihttps://repositorio.ubiobio.cl/handle/123456789/10133
dc.languagespa
dc.publisherFOOD AND CHEMICAL TOXICOLOGY
dc.relation.uri10.1016/j.fct.2018.07.055
dc.rightsPUBLICADA
dc.titleEFFECT OF METAL IN SCHIFF BASES OF CHITOSAN ADSORBED ON GLASSY CARBON ELECTRODE IN THE INHIBITION OF SPHINGOMYELINASE C TOXIN.
dc.title.alternativeEFECTO DEL METAL EN BASES SCHIFF DE QUITOSANO ADSORBIDO SOBRE ELECTRODO DE CARBONO VÍTREO EN LA INHIBICIÓN DE LA TOXINA C DE LA ESFINGOMIELINASA C
dc.typeARTÍCULO
dspace.entity.typePublication
ubb.EstadoPUBLICADA
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.Otra ReparticionDEPARTAMENTO DE CIENCIAS BASICAS
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
ubb.SedeCHILLÁN
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