Publicación: MECHANICAL PROPERTIES OF BILAYERS CONTAINING SPERM SPHINGOMYELINS AND CERAMIDES WITH VERY LONG-CHAIN POLYUNSATURATED FATTY ACIDS
Fecha
2019
Autores
Título de la revista
ISSN de la revista
Título del volumen
Editor
CHEMISTRY AND PHYSICS OF LIPIDS
Resumen
SPHINGOMYELINS (SM) AND CERAMIDES (CER) WITH VERY LONG CHAIN POLYUNSATURATED FATTY ACIDS (V) ARE IMPORTANT COMPONENTS OF SPERMATOZOA MEMBRANES. IN THIS STUDY, THE MECHANICAL PROPERTIES OF BILAYERS OF SM AND CER WITH NONHYDROXY (N-V) AND 2-HYDROXY (H-V) FATTY ACID (30:5) WERE STUDIED BY MOLECULAR DYNAMICS SIMULATION AT DIFFERENT TEMPERATURES AND IN THE PRESENCE AND THE ABSENCE OF SALT. FROM OUR RESULTS, IT WAS EVIDENCED HOW N-V SM AND H-V SM BILAYERS SHOWED SIMILAR BEHAVIOR. WHEN N-V CER WAS ADDED TO A H-V SM BILAYER, THE GAUSSIAN CURVATURE MODULUS AND E-CURVE OF BINARY BILAYERS DECREASED. THIS VARIATION IN THE MECHANICAL PROPERTIES OF THE BILAYER CAN BE ASSOCIATED WITH AN INCIPIENT STEP DURING THE FECUNDATION PROCESS.
