Publicación: HEMI-SYNTHESIS AND ANTI-OOMYCETE ACTIVITY OF ANALOGUES OF ISOCORDOIN

Fecha
2017
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MOLECULES AND CELLS
Resumen
AN EFFICIENT SYNTHESIS OF A SERIES OF 4-OXYALKYL-ISOCORDOIN ANALOGUES (2-8) IS REPORTED FOR THE FIRST TIME. THEIR STRUCTURES WERE CONFIRMED BY ¹H-NMR, 13C-NMR, AND HRMS. THEIR ANTI-OOMYCETE ACTIVITY WAS EVALUATED BY MYCELIUM AND SPORES INHIBITION ASSAY AGAINST TWO SELECTED PATHOGENIC OOMYCETES STRAINS: SAPROLEGNIA PARASITICA AND SAPROLEGNIA AUSTRALIS. THE ENTIRE SERIES OF ISOCORDOIN DERIVATIVES (EXCEPT COMPOUND 7) SHOWED HIGH INHIBITORY ACTIVITY AGAINST THESE OOMYCETE STRAINS. AMONG THEM, COMPOUND 2 EXHIBITED STRONG ACTIVITY, WITH MINIMUM INHIBITORY CONCENTRATION (MIC) AND MINIMUM OOMYCETICIDAL CONCENTRATION (MOC) VALUES OF 50 µG/ML AND 75 µG/ML, RESPECTIVELY. THE RESULTS SHOWED THAT 4-OXYALKYLATED ANALOGUES OF ISOCORDOIN COULD BE POTENTIAL ANTI-OOMYCETE AGENTS.