Publicación:
HEMI-SYNTHESIS AND ANTI-OOMYCETE ACTIVITY OF ANALOGUES OF ISOCORDOIN

Imagen por defecto
Fecha
2017
Título de la revista
ISSN de la revista
Título del volumen
Editor
MOLECULES AND CELLS
Proyectos de investigación
Unidades organizativas
Número de la revista
Resumen
AN EFFICIENT SYNTHESIS OF A SERIES OF 4-OXYALKYL-ISOCORDOIN ANALOGUES (2-8) IS REPORTED FOR THE FIRST TIME. THEIR STRUCTURES WERE CONFIRMED BY ¹H-NMR, 13C-NMR, AND HRMS. THEIR ANTI-OOMYCETE ACTIVITY WAS EVALUATED BY MYCELIUM AND SPORES INHIBITION ASSAY AGAINST TWO SELECTED PATHOGENIC OOMYCETES STRAINS: SAPROLEGNIA PARASITICA AND SAPROLEGNIA AUSTRALIS. THE ENTIRE SERIES OF ISOCORDOIN DERIVATIVES (EXCEPT COMPOUND 7) SHOWED HIGH INHIBITORY ACTIVITY AGAINST THESE OOMYCETE STRAINS. AMONG THEM, COMPOUND 2 EXHIBITED STRONG ACTIVITY, WITH MINIMUM INHIBITORY CONCENTRATION (MIC) AND MINIMUM OOMYCETICIDAL CONCENTRATION (MOC) VALUES OF 50 µG/ML AND 75 µG/ML, RESPECTIVELY. THE RESULTS SHOWED THAT 4-OXYALKYLATED ANALOGUES OF ISOCORDOIN COULD BE POTENTIAL ANTI-OOMYCETE AGENTS.
Descripción
Palabras clave
Citación