Publicación: HEMI-SYNTHESIS AND ANTI-OOMYCETE ACTIVITY OF ANALOGUES OF ISOCORDOIN
| dc.creator | ENRIQUE ADALBERTO WERNER NAVARRETE | |
| dc.date | 2017 | |
| dc.date.accessioned | 2025-01-10T14:41:09Z | |
| dc.date.available | 2025-01-10T14:41:09Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | AN EFFICIENT SYNTHESIS OF A SERIES OF 4-OXYALKYL-ISOCORDOIN ANALOGUES (2-8) IS REPORTED FOR THE FIRST TIME. THEIR STRUCTURES WERE CONFIRMED BY ¹H-NMR, 13C-NMR, AND HRMS. THEIR ANTI-OOMYCETE ACTIVITY WAS EVALUATED BY MYCELIUM AND SPORES INHIBITION ASSAY AGAINST TWO SELECTED PATHOGENIC OOMYCETES STRAINS: SAPROLEGNIA PARASITICA AND SAPROLEGNIA AUSTRALIS. THE ENTIRE SERIES OF ISOCORDOIN DERIVATIVES (EXCEPT COMPOUND 7) SHOWED HIGH INHIBITORY ACTIVITY AGAINST THESE OOMYCETE STRAINS. AMONG THEM, COMPOUND 2 EXHIBITED STRONG ACTIVITY, WITH MINIMUM INHIBITORY CONCENTRATION (MIC) AND MINIMUM OOMYCETICIDAL CONCENTRATION (MOC) VALUES OF 50 µG/ML AND 75 µG/ML, RESPECTIVELY. THE RESULTS SHOWED THAT 4-OXYALKYLATED ANALOGUES OF ISOCORDOIN COULD BE POTENTIAL ANTI-OOMYCETE AGENTS. | |
| dc.format | application/pdf | |
| dc.identifier.doi | 10.3390/moléculas22060968 | |
| dc.identifier.issn | 1420-3049 | |
| dc.identifier.issn | 0219-1032 | |
| dc.identifier.issn | 1016-8478 | |
| dc.identifier.uri | https://repositorio.ubiobio.cl/handle/123456789/8516 | |
| dc.language | spa | |
| dc.publisher | MOLECULES AND CELLS | |
| dc.relation.uri | 10.3390/moléculas22060968 | |
| dc.rights | PUBLICADA | |
| dc.title | HEMI-SYNTHESIS AND ANTI-OOMYCETE ACTIVITY OF ANALOGUES OF ISOCORDOIN | |
| dc.title.alternative | HEMISÍNTESIS Y ACTIVIDAD ANTIOMICETO DE ANÁLOGOS DE ISOCORDOÍNA | |
| dc.type | ARTÍCULO | |
| dspace.entity.type | Publication | |
| ubb.Estado | PUBLICADA | |
| ubb.Otra Reparticion | DEPARTAMENTO DE CIENCIAS BASICAS | |
| ubb.Sede | CHILLÁN |
