Publicación: BIOPSYCHOSOCIAL PERSPECTIVES ON HEALTHY BRAIN AGING: A NARRATIVE REVIEW
Fecha
2025
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JOURNAL OF AGEING AND LONGEVITY
Resumen
THE GLOBAL RISE IN THE ELDERLY POPULATION INHERENTLY ESCALATES THE DEMAND FOR HEALTH AND SOCIAL CARE. ENSURING COGNITIVE PERFORMANCE FOR HEALTHY BRAIN AGING PRESENTS SIGNIFICANT CHALLENGES FOR RESEARCHERS AND HEALTH PROFESSIONALS PROMOTING SELF-CARE BEHAVIORS. THIS ARTICLE AIMS TO PROVIDE A COMPREHENSIVE AND CRITICAL ANALYSIS OF THE LATEST RESEARCH ON HEALTHY BRAIN AGING BY EMPLOYING A BIOPSYCHOSOCIAL FRAMEWORK. IT INTEGRATES BIOLOGICAL, PSYCHOLOGICAL, AND SOCIAL DIMENSIONS TO ELUCIDATE THEIR COLLECTIVE INFLUENCE ON COGNITIVE HEALTH IN OLDER ADULTS. METHODOLOGICALLY, THIS ARTICLE PROVIDES A NARRATIVE REVIEW OF THE EXISTING LITERATURE. A DIVERSE ARRAY OF BIBLIOGRAPHIC RESOURCES WAS OBTAINED FROM PROMINENT ELECTRONIC DATABASES, INCLUDING MEDLINE, PUBMED, SCOPUS AND WEB OF SCIENCE, TO ENSURE BROAD COVERAGE OF THE TOPIC. THE SEARCH WAS DESIGNED TO CAPTURE RELEVANT STUDIES PUBLISHED BETWEEN 2010 AND 2025, USING KEY TERMS SUCH AS ?AGING?, ?BIOMARKER?, ?NEURODEGENERATION?, AND ?COGNITIVE PERFORMANCE?. FOLLOWING A RIGOROUS SELECTION PROCESS, TWO FIELD SPECIALISTS EVALUATED A TOTAL OF 106 FULL-TEXT ARTICLES TO IDENTIFY THOSE THAT MET THE ELIGIBILITY CRITERIA, ULTIMATELY YIELDING 70 RELEVANT STUDIES. THE FINDINGS REVEAL IMPORTANT CONNECTIONS BETWEEN PSYCHOSOCIAL AND BIOLOGICAL BIOMARKERS AND BRAIN MORPHOLOGY, HIGHLIGHTING LIFESTYLE FACTORS?SUCH AS DIET, EXERCISE, AND SOCIAL ENGAGEMENT?AS CRUCIAL FOR COGNITIVE HEALTH. THE ARTICLE ALSO UNDERSCORES SPECIFIC BIOMARKERS RELEVANT FOR ASSESSING BRAIN AGE AND THEIR RELATIONSHIP TO NEURODEGENERATIVE DISORDERS. NOTABLY, WHILE BIOLOGICAL MARKERS LIKE A?, TAU, AND ?-SYNUCLEIN (PROTEINS THAT DEFINE THE CORE MOLECULAR PATHOLOGY OF COMMON NEURODEGENERATIVE DISEASES) ARE PRESENT, THEY DO NOT GUARANTEE THE ONSET OF NEURODEGENERATIVE DISEASES; PSYCHOSOCIAL FACTORS PLAY AN ESSENTIAL ROLE IN DETERMINING DISEASE MANIFESTATION.
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quality life, cognitive health, brain aging, psychosocial factors, biological factors, aging
