Publicación: ADJUVANT PROPERTIES OF CAFFEIC ACID IN CANCER TREATMENT
Fecha
2024
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Resumen
CAFFEIC ACID (CA) IS A POLYPHENOL BELONGING TO THE PHENYLPROPANOID FAMILY, COMMONLY
FOUND IN PLANTS AND VEGETABLES. IT WAS FIRST IDENTIFIED BY HLASIWETZ IN 1867 AS A BREAKDOWN PRODUCT
OF CAFFETANNIC ACID. CA IS BIOSYNTHESIZED FROM THE AMINO ACIDS TYROSINE OR PHENYLALANINE THROUGH
SPECIFIC ENZYME-CATALYZED REACTIONS. EXTENSIVE RESEARCH SINCE ITS DISCOVERY HAS REVEALED VARIOUS
HEALTH BENEFITS ASSOCIATED WITH CA, INCLUDING ITS ANTIOXIDANT, ANTI-INFLAMMATORY, AND ANTICANCER
PROPERTIES. THESE EFFECTS ARE ATTRIBUTED TO ITS ABILITY TO MODULATE SEVERAL PATHWAYS, SUCH AS INHIBITING
NFKB, STAT3, AND ERK1/2, THEREBY REDUCING INFLAMMATORY RESPONSES, AND ACTIVATING THE NRF2/ARE
PATHWAY TO ENHANCE ANTIOXIDANT CELL DEFENSES. THE CONSUMPTION OF CA HAS BEEN LINKED TO A REDUCED
RISK OF CERTAIN CANCERS, MITIGATION OF CHEMOTHERAPY AND RADIOTHERAPY-INDUCED TOXICITY, AND REVERSAL
OF RESISTANCE TO FIRST-LINE CHEMOTHERAPEUTIC AGENTS. THIS SUGGESTS THAT CA COULD SERVE AS A USEFUL
ADJUNCT IN CANCER TREATMENT. STUDIES HAVE SHOWN CA TO BE GENERALLY SAFE, WITH FEW ADVERSE EFFECTS
(SUCH AS BACK PAIN AND HEADACHES) REPORTED. THIS REVIEW COLLATES THE LATEST INFORMATION FROM GOOGLE
SCHOLAR, PUBMED, THE PHENOL-EXPLORER DATABASE, AND CLINICALTRIALS.GOV, INCORPORATING A TOTAL OF
154 ARTICLES, TO UNDERSCORE THE POTENTIAL OF CA IN CANCER PREVENTION AND OVERCOMING CHEMORESISTANCE.
Descripción
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vegetal sources, metabolism, caffeic acid, adjuvant cancer treatment
