Publicación: A ROBUST QUANTITATIVE APPROACH FOR LASER SPECKLE CONTRAST IMAGING PERFUSION ANALYSIS REVEALED ANOMALIES IN THE BRAIN BLOOD FLOW IN OFFSPRING MICE OF PREECLAMPSIA
Fecha
2022
Título de la revista
ISSN de la revista
Título del volumen
Editor
MICROVASCULAR RESEARCH
Resumen
MICROCIRCULATION ANALYSIS OF THE BRAIN CORTEX IS CHALLENGING BECAUSE SURFACE PERFUSION VARIES RAPIDLY IN SMALL SPACE-TIME REGIONS AND IS BONE PROTECTED. THE LASER SPECKLE CONTRAST IMAGING (LSCI) TECHNIQUE ALLOWS ANALYZING IN VIVO BRAIN VASCULAR PERFUSION GENERATING A LARGE AMOUNT OF DATA THAT REQUIRES SOPHISTICATED DATA ANALYTICS, MAKING RESEARCHERS INVEST MUCH EFFORT IN PROCESSING. OUR RESEARCH QUESTION WAS WHETHER THE REDUCED PLACENTAL PERFUSION MODEL (RUPP) OF PREECLAMPSIA (PE) WAS ASSOCIATED WITH IMPAIRED BLOOD PERFUSION IN THE OFFSPRING BRAINS.
Descripción
Palabras clave
Deterioro cognitivo, Dimorfismo sexual, Enfoque cuantitativo, Imágenes de contraste moteado láser, Microcirculación cerebral, Modelo Rupp de preeclampsia, Respuesta vascular, Vascular response, Sex-dimorphism, RUPP model of preeclampsia, Quantitative approach, Laser speckle contrast imaging, Cognitive decline, Brain microcirculation
